中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2013年
10期
1497-1499
,共3页
心房颤动%血管紧张素Ⅱ%C反应蛋白质%利钠肽,脑
心房顫動%血管緊張素Ⅱ%C反應蛋白質%利鈉肽,腦
심방전동%혈관긴장소Ⅱ%C반응단백질%리납태,뇌
Atrial fibrillation%Angiotensin Ⅱ%C-Reactive protein%Natrinuretic peptide,brain
目的 探讨血清血管紧张素Ⅱ(AngⅡ)、超敏C反应蛋白(hs-CRP)和脑钠肽(BNP)水平与心房颤动的关系及临床意义,以及影响心房颤动复发的危险因素.方法 选取100例心房颤动的患者,分为阵发性房颤组54例,持续性房颤组46例,并与50例对照组比较分析.应用放射免疫法检血清AngⅡ及BNP水平,免疫比浊法检测hs-CRP水平.结果 心房颤动组血清AngⅡ、hs-CRP和BNP水平均显著高于对照组(均P＜0.01),且持续性房颤组中AngⅡ、hs-CRP显著高于阵发性房颤组(P＜0.01)；线性相关分析表明AngⅡ、hs-CRP水平与BNP水平呈明显正相关(r=0.563、0.678,均P＜0.01)；AngⅡ水平与hs-CRP水平呈正相关(r =0.626,P＜0.01)；Logistic回归分析结果表明,hs-CRP、BNP与心房颤动复发关系密切[OR值=2.42,95％CI(1.84 5.26)；OR值=2.14,95％ CI(1.37 ～3.86)].结论 AngⅡ、hs-CRP及BNP在心房颤动发生、发展过程中可能起重要作用,血清hs-CRP和BNP可能是心房颤动的独立危险因素,联合检测对心房颤动的复发有一定的预测作用.
目的 探討血清血管緊張素Ⅱ(AngⅡ)、超敏C反應蛋白(hs-CRP)和腦鈉肽(BNP)水平與心房顫動的關繫及臨床意義,以及影響心房顫動複髮的危險因素.方法 選取100例心房顫動的患者,分為陣髮性房顫組54例,持續性房顫組46例,併與50例對照組比較分析.應用放射免疫法檢血清AngⅡ及BNP水平,免疫比濁法檢測hs-CRP水平.結果 心房顫動組血清AngⅡ、hs-CRP和BNP水平均顯著高于對照組(均P＜0.01),且持續性房顫組中AngⅡ、hs-CRP顯著高于陣髮性房顫組(P＜0.01)；線性相關分析錶明AngⅡ、hs-CRP水平與BNP水平呈明顯正相關(r=0.563、0.678,均P＜0.01)；AngⅡ水平與hs-CRP水平呈正相關(r =0.626,P＜0.01)；Logistic迴歸分析結果錶明,hs-CRP、BNP與心房顫動複髮關繫密切[OR值=2.42,95％CI(1.84 5.26)；OR值=2.14,95％ CI(1.37 ～3.86)].結論 AngⅡ、hs-CRP及BNP在心房顫動髮生、髮展過程中可能起重要作用,血清hs-CRP和BNP可能是心房顫動的獨立危險因素,聯閤檢測對心房顫動的複髮有一定的預測作用.
목적 탐토혈청혈관긴장소Ⅱ(AngⅡ)、초민C반응단백(hs-CRP)화뇌납태(BNP)수평여심방전동적관계급림상의의,이급영향심방전동복발적위험인소.방법 선취100례심방전동적환자,분위진발성방전조54례,지속성방전조46례,병여50례대조조비교분석.응용방사면역법검혈청AngⅡ급BNP수평,면역비탁법검측hs-CRP수평.결과 심방전동조혈청AngⅡ、hs-CRP화BNP수평균현저고우대조조(균P＜0.01),차지속성방전조중AngⅡ、hs-CRP현저고우진발성방전조(P＜0.01)；선성상관분석표명AngⅡ、hs-CRP수평여BNP수평정명현정상관(r=0.563、0.678,균P＜0.01)；AngⅡ수평여hs-CRP수평정정상관(r =0.626,P＜0.01)；Logistic회귀분석결과표명,hs-CRP、BNP여심방전동복발관계밀절[OR치=2.42,95％CI(1.84 5.26)；OR치=2.14,95％ CI(1.37 ～3.86)].결론 AngⅡ、hs-CRP급BNP재심방전동발생、발전과정중가능기중요작용,혈청hs-CRP화BNP가능시심방전동적독립위험인소,연합검측대심방전동적복발유일정적예측작용.
Objective To explore the clinical signifcance of changes of serum Ang Ⅱ,hs-CRP and BNP levels and the relationship with atrial fibrillation(AF),and the risk factors of AF recurrence.Methods 100 patients with AF were selected in this study,and they were divided into two groups:paroxysmal atrial fibrillation group (n =54),durative atrial fibrillation group(n =46),and 50 healthy subjects were selected as control.The levels of serum Ang Ⅱ,BNP were detected by radioimmunoassay,and hs-CRP was detected by immunoturbidimetry.Results The levels of Ang Ⅱ,hs-CRP and BNP in atrial fibrillation patients were significantly increased as compared to control group (P ＜ 0.01).The levels of Ang Ⅱ,hs-CRP in the durative atrial fibrillation group were higher than those in the paroxysmal atrial fibrillation group.The levels of serum Ang Ⅱ,hs-CRP were positively correlated with serum BNP level (r =0.563,0.678,all P ＜0.01).The level of serum Ang Ⅱ was positively correlated with serum hs-CRP level(r =0.626,P ＜ 0.01).Multiple logistic regression analysis revealed that hs-CRP and BNP were the important risk factors of atrial fibrillation recurrence[OR value =2.42,95％ CI(1.84 ～ 5.26) ;OR value =2.14,95％ CI(1.37 ～.86)].Conclusion The serum AngⅡ,hs-CRP and BNP may play important roles in the development of AF.hs-CRP and BNP may be the independent risk factors of AF.The detection of hs-CRP and BNP may be related to recurrence prognosis in patients with AF.
