CAJ | 학술논문

目的：探讨双源CT灌注成像参数对兔肝纤维化分期的价值。方法35只新西兰大白兔四氯化碳腹腔注射建立肝纤维化模型(实验组),5只腹腔注射生理盐水(对照组)。分别在第4、6、8、10、12周取实验组模型7只及对照组1只行双源CT灌注成像扫描。采集灌注参数,包括肝动脉灌注量(ALP),肝门静脉灌注量(PVP),肝总灌注量(THP)及肝动脉灌注指数(HPI),并与病理分期进行对照研究。结果随着肝纤维化程度的增加,肝动脉灌注指数也呈上升趋势,而门静脉灌注量呈下降趋势。统计显示 S2、S3、S4期与对照组,S3、S4期与 S0期,S3、S4期与 S1期比较,HPI 有统计学差异。S2、S3、S4期与 S0、S1期比较,PVP 有统计学差异。结论 HPI和PVP能够反映肝纤维化各期灌注变化,二者结合,可以对 S2、S3、S4期纤维化作出诊断。
목적：탐토쌍원CT관주성상삼수대토간섬유화분기적개치。방법35지신서란대백토사록화탄복강주사건립간섬유화모형(실험조),5지복강주사생리염수(대조조)。분별재제4、6、8、10、12주취실험조모형7지급대조조1지행쌍원CT관주성상소묘。채집관주삼수,포괄간동맥관주량(ALP),간문정맥관주량(PVP),간총관주량(THP)급간동맥관주지수(HPI),병여병리분기진행대조연구。결과수착간섬유화정도적증가,간동맥관주지수야정상승추세,이문정맥관주량정하강추세。통계현시 S2、S3、S4기여대조조,S3、S4기여 S0기,S3、S4기여 S1기비교,HPI 유통계학차이。S2、S3、S4기여 S0、S1기비교,PVP 유통계학차이。결론 HPI화PVP능구반영간섬유화각기관주변화,이자결합,가이대 S2、S3、S4기섬유화작출진단。
Objective To investigate the value of dual-source CT perfusion imaging in evaluation of liver fibrosis stage.Methods Liver fibrosis models were established with 35 rabbits (experimental group)which were intraperitoneally injected with carbon tetra-chloride.Meanwhile,other 5 rabbits were regarded as control group which were intraperitoneally inj eced with physiological saline.7 rabbits of experimental group and 1 of control group were undergone dual-source CT perfusion scan at 4,6,8,10,12 weeks respec-tively.Arterial liver perfusion (ALP),portal venous perfusion (PVP),total hepatic perfusion (THP),hepatic perfusion index (HPI)were recorded,and staging of liver fibrosis were assessed by pathological method.Results With the increase of liver fibrosis degree,HPI showed an upward trend,whereas PVP was opposite.HPIs of S2,S3 and S4 stage were significantly different com-pared to that of control group respectively.The differences of HPI between S3,S4 stage to S0 and S1 stage were significant.PVP between S2,S3,S4 stage to S0 stage and S1 stage were also significant different.Conclusion HPI and PVP can reflect the perfu-sion changes of liver fibrosis stages.Combination of HPI and PVP may help the diagnosis of S2,S3 or S4 stage of liver fibrosis.