CAJ | 학술논문

目的探讨大分割三维适型放射治疗转移瘤的方法和疗效。方法采用CT定位，CMS治疗计划系统三维适型大分割放射治疗肺转移瘤45例，共计66个病灶，病灶大小0.5~5.0cm，＜3.0cm 47个，3.0~5.0cm 19个。辐射源为6MVX线，单次照射剂量5GY，隔日照射，总剂量50GY/10F。结果肿瘤消失11灶（28.9%），转移灶缩小（PR）的有38灶（62.2%），总有效率74.2%，病灶＜3cm者有效率为82.97%，明显高于肿瘤≥3cm者（P＜0.01）。全组患者1，2，3年生存率分别为55.6%（25/45），35.6%（16/45），17.8%（8/45）。结论大分割三维适型放射治疗是治疗肺转移瘤的有效方法，其近期疗效与转移灶大小有关。
목적탐토대분할삼유괄형방사치료전이류적방법화료효。방법채용CT정위，CMS치료계화계통삼유괄형대분할방사치료폐전이류45례，공계66개병조，병조대소0.5~5.0cm，＜3.0cm 47개，3.0~5.0cm 19개。복사원위6MVX선，단차조사제량5GY，격일조사，총제량50GY/10F。결과종류소실11조（28.9%），전이조축소（PR）적유38조（62.2%），총유효솔74.2%，병조＜3cm자유효솔위82.97%，명현고우종류≥3cm자（P＜0.01）。전조환자1，2，3년생존솔분별위55.6%（25/45），35.6%（16/45），17.8%（8/45）。결론대분할삼유괄형방사치료시치료폐전이류적유효방법，기근기료효여전이조대소유관。
Objective To explore the methodsand effects of 3D-CRT with hypofractionated high-dose in the treatment of lung metastases. Methods From Jul.2008 to Nov.2011,45 cases with lung metastases were treated by 3D-CRT with hypofractionated high-dose in our hospital. The total number of the metastases were 66.The diameter of the metastases was 0.5-5.0cm.less than 3.0cm in 47,3.0-5.0cm in 19.6MV.X-ray was chosen as radiationsource. The dose per fraction was 5GY, and the total prescribed dose was 50GY at the margin of the PTV enveloped by 95%insodose curve. Result Local regression of the metastases were evaluated by CT image obtained in 3 months after treatment. Complete regression was found in 11 foci(28.9%), partial regression in 38 foci(62.2%), and the overall effective rate was 74.2.The effective rate for the foci with diameter less than 3 cm was 82.97%,and 52.6%equal or more than 3cm,there was signiifcantly different(P<0.01).Conclusion The measure was an effective treatment method, for patients with Lung metratases.