CAJ | 학술논문

目的观察右美托咪啶复合丙泊酚用于结肠镜下治疗结肠息肉的麻醉效果及安全性。方法100例ASAI~III级拟行结肠镜下治疗结肠息肉的患者，年龄26~75岁，体质量45~76kg，随机分为右美托咪啶复合丙泊酚组（D组）和丙泊酚组（P组），每组50例。记录患者给药前（T0），给药后5min（T1），过脾曲时（T2），过肝曲时（T3），切除息肉时（T4）及苏醒时（T5）的HR、MAP、RR、SpO2的变化，镇静评分，手术时间，苏醒时间，丙泊酚总用量，麻醉后不良反应发生率。结果所有患者均能完成操作，D组T1-T5时HR慢于T0及P组（P＜0.05）。两组T1时MAP及SpO2均低于T0时（P＜0.05），T1-T5时两组的HR、MAP无统计学意义，T1时D组SpO2高于P组（P＜0.05）表3。T1时D组SpO2高于P组（P＜0.05）。两组手术及苏醒时间无差异，D组丙泊酚总用量少于P组（P＜0.05）。D组镇静评分优于P组（P＜0.01），不良反应发生率均少于P组（P＜0.05）。结论右美托咪定复合丙泊酚麻醉用于结肠镜下结肠息肉的治疗，可产生良好的镇痛作用，并能节省丙泊酚的用量，是一种安全有效的麻醉方法。
목적관찰우미탁미정복합병박분용우결장경하치료결장식육적마취효과급안전성。방법100례ASAI~III급의행결장경하치료결장식육적환자，년령26~75세，체질량45~76kg，수궤분위우미탁미정복합병박분조（D조）화병박분조（P조），매조50례。기록환자급약전（T0），급약후5min（T1），과비곡시（T2），과간곡시（T3），절제식육시（T4）급소성시（T5）적HR、MAP、RR、SpO2적변화，진정평분，수술시간，소성시간，병박분총용량，마취후불량반응발생솔。결과소유환자균능완성조작，D조T1-T5시HR만우T0급P조（P＜0.05）。량조T1시MAP급SpO2균저우T0시（P＜0.05），T1-T5시량조적HR、MAP무통계학의의，T1시D조SpO2고우P조（P＜0.05）표3。T1시D조SpO2고우P조（P＜0.05）。량조수술급소성시간무차이，D조병박분총용량소우P조（P＜0.05）。D조진정평분우우P조（P＜0.01），불량반응발생솔균소우P조（P＜0.05）。결론우미탁미정복합병박분마취용우결장경하결장식육적치료，가산생량호적진통작용，병능절성병박분적용량，시일충안전유효적마취방법。
Objective To observe the efifcacy and safety of dexmedetomidine combinee with propofol in treatment colon polyps used colonoscopy. Methods 100 cases of patients ASA I-III taking resection of colon polyps(age:26-75,weight 45-76kg) were randomly divided into two group:group D(50 cases):dexmedetomidine combined with propofol ,group P(50 cases) propofol.The scale of anethetic effect. Operation time,recover time,total amount of propofol incidence of adverse reactions. HR, MAP, RR, SpO2 at before anesthesia(T0),5min after injection(T1),passing the splentic lfexure(T2),passing the hepatic lfexure(T3),removing polyps(T4) and awake(T5)were monitored. Results All patients were able to complete the operation .HR of group D lower than T0 and group P(P<0.05).Two group of MAP and SpO2 were lower than T0 ,HR and MAP of two group are not statistically signiifcant at T1-T5. SpO2 of group D is higher than P group at T1 (P<0.05).D group’s calm score is better than that of P group(P<0.01),incidence of adverse reactions are less than P group(P<0.05). Conclusion The anesthetic effect of demedetomidine combined with propofol in treatment colon polyps use colonoscopy is satifactory and safety.