山西医药杂志
山西醫藥雜誌
산서의약잡지
SHANXI MEDICAL JOURNAL
2014年
9期
997-999
,共3页
头颈部肿瘤%血管内皮生长因子类%受体,表皮生长因子
頭頸部腫瘤%血管內皮生長因子類%受體,錶皮生長因子
두경부종류%혈관내피생장인자류%수체,표피생장인자
Head and neck neoplasms%Vascular endothelial growth factors%Receptor,epidermal growth factor
目的：探讨头颈部鳞癌患者血清血管内皮生长因子（VEGF）和人表皮生长因子受体-2（HER2）表达情况与临床病理参数的关系以及二者之间的相互关系。方法收集60例头颈部鳞癌患者血清和30名健康体检者血清，应用酶联免疫吸附试验（ELISA）定量检测血清 VEGF和 HER2表达水平变化。结果试验组血清中 VEGF的表达水平显著高于对照组（P＜0.05），而2组血清 HER2的差异不明显（P＞0.05）。血清 VEGF在鳞癌中的表达率随着分化程度的递减而增加，且淋巴结转移组血清 VEGF水平显著高于无淋巴结转移组（P＜0.05）。但血清VEGF表达与年龄、性别、肿瘤浸润深度等临床病理参数差异无统计学意义（P＞0.05）。HER2的表达在各病理参数间差异无统计学意义（P＞0.05）。二者的表达无相关性（r＝0.147，P＞0.05）。结论 VEGF在头颈部鳞癌的发生发展过程中发挥重要作用，其与疾病的侵袭和转移有关，是重要的预后不良因子。而 HER2在头颈部鳞癌发生发展中作用尚不确定。
目的：探討頭頸部鱗癌患者血清血管內皮生長因子（VEGF）和人錶皮生長因子受體-2（HER2）錶達情況與臨床病理參數的關繫以及二者之間的相互關繫。方法收集60例頭頸部鱗癌患者血清和30名健康體檢者血清，應用酶聯免疫吸附試驗（ELISA）定量檢測血清 VEGF和 HER2錶達水平變化。結果試驗組血清中 VEGF的錶達水平顯著高于對照組（P＜0.05），而2組血清 HER2的差異不明顯（P＞0.05）。血清 VEGF在鱗癌中的錶達率隨著分化程度的遞減而增加，且淋巴結轉移組血清 VEGF水平顯著高于無淋巴結轉移組（P＜0.05）。但血清VEGF錶達與年齡、性彆、腫瘤浸潤深度等臨床病理參數差異無統計學意義（P＞0.05）。HER2的錶達在各病理參數間差異無統計學意義（P＞0.05）。二者的錶達無相關性（r＝0.147，P＞0.05）。結論 VEGF在頭頸部鱗癌的髮生髮展過程中髮揮重要作用，其與疾病的侵襲和轉移有關，是重要的預後不良因子。而 HER2在頭頸部鱗癌髮生髮展中作用尚不確定。
목적：탐토두경부린암환자혈청혈관내피생장인자（VEGF）화인표피생장인자수체-2（HER2）표체정황여림상병리삼수적관계이급이자지간적상호관계。방법수집60례두경부린암환자혈청화30명건강체검자혈청，응용매련면역흡부시험（ELISA）정량검측혈청 VEGF화 HER2표체수평변화。결과시험조혈청중 VEGF적표체수평현저고우대조조（P＜0.05），이2조혈청 HER2적차이불명현（P＞0.05）。혈청 VEGF재린암중적표체솔수착분화정도적체감이증가，차림파결전이조혈청 VEGF수평현저고우무림파결전이조（P＜0.05）。단혈청VEGF표체여년령、성별、종류침윤심도등림상병리삼수차이무통계학의의（P＞0.05）。HER2적표체재각병리삼수간차이무통계학의의（P＞0.05）。이자적표체무상관성（r＝0.147，P＞0.05）。결론 VEGF재두경부린암적발생발전과정중발휘중요작용，기여질병적침습화전이유관，시중요적예후불량인자。이 HER2재두경부린암발생발전중작용상불학정。
Objective To investigate the expression of serum VEGF and HER2 in patients with head and neck squamous cell carcinoma,and to analyze the correlation between the expression and clinical pathological parameters and the correlation of them.Methods ELISA was used to detect the serum level of VEGF and HER2 in 60 head and neck squamous cell carcinoma patients and 30 healthy control.Results The expression of serum VEGF in the experimental group was significantly higher than that of control group (P<0.05).But there were no significance of HER2 protein ex-pression between the two groups (P>0.05).The serum level of VEGF in patients with head and neck squamous cell car-cinoma showed gradual increase with histological grades advancing,and the expression in the lymph node metastasis group is significantly higher than that of no lymph node metastasis (P<0.05).Furthermore,there was no correlation between VEGF and gender,age,the depth of invasion (P>0.05).No correlation was obtained between HER2 and gender,age, the depth of invasion or lymph node metastasis(P>0.05).No relationship was found between HER2 and VEGF either (r=0.147,P>0.05).Conclusion VEGF is closely related to the occurrence and development of head and neck squa-mous cell carcinoma,which is associated with the invasion and metastasis of the disease.It is the important prognosis fac-tor.The role of HER2 in the development of head and neck squamous cell carcinoma is still not determined.
