中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2013年
26期
16-17,18
,共3页
幽门螺杆菌%序贯疗法%三联疗法
幽門螺桿菌%序貫療法%三聯療法
유문라간균%서관요법%삼련요법
Helicobacter pylori%Sequential therapy%Triple therapy
目的：观察10 d序贯疗法与10 d标准疗法抗幽门螺杆菌疗效，以寻找新的抗幽门螺杆菌方案。方法：2010年5月-2012年4月在本院消化内科住院或门诊治疗、随访的127例患者，经胃镜检查确诊为活动性消化性溃疡并且Hp检查为阳性的患者进行研究。对入选患者分为序贯治疗组与标准治疗组两组，均要求奥美拉唑饭前服，抗生素饭后服，共10 d。停药4周后再行胃镜检查或13C尿素呼气试验以观疗效，对两组的根除率均按意向性治疗分析（ITT），统计学分析采用SPSS 20.0医学统计软件进行字2检验比较。结果：Hp根除率比较：序贯治疗组Hp根除率为95.16%，10 d标准治疗组根除率为81.53%，序贯治疗组的根除率高于标准治疗组，差异有统计学意义（P<0.05）；在研究期间两组均无上消化道大出血等严重不良反应发生。两组副反应发生率分别为10/62（16.13%）、10/65（15.38%），差异无统计学意义（P>0.05）。结论：研究表明，抗幽门螺杆菌治疗10 d序贯疗法优于标准三联疗法，具有较高的Hp根除率。
目的：觀察10 d序貫療法與10 d標準療法抗幽門螺桿菌療效，以尋找新的抗幽門螺桿菌方案。方法：2010年5月-2012年4月在本院消化內科住院或門診治療、隨訪的127例患者，經胃鏡檢查確診為活動性消化性潰瘍併且Hp檢查為暘性的患者進行研究。對入選患者分為序貫治療組與標準治療組兩組，均要求奧美拉唑飯前服，抗生素飯後服，共10 d。停藥4週後再行胃鏡檢查或13C尿素呼氣試驗以觀療效，對兩組的根除率均按意嚮性治療分析（ITT），統計學分析採用SPSS 20.0醫學統計軟件進行字2檢驗比較。結果：Hp根除率比較：序貫治療組Hp根除率為95.16%，10 d標準治療組根除率為81.53%，序貫治療組的根除率高于標準治療組，差異有統計學意義（P<0.05）；在研究期間兩組均無上消化道大齣血等嚴重不良反應髮生。兩組副反應髮生率分彆為10/62（16.13%）、10/65（15.38%），差異無統計學意義（P>0.05）。結論：研究錶明，抗幽門螺桿菌治療10 d序貫療法優于標準三聯療法，具有較高的Hp根除率。
목적：관찰10 d서관요법여10 d표준요법항유문라간균료효，이심조신적항유문라간균방안。방법：2010년5월-2012년4월재본원소화내과주원혹문진치료、수방적127례환자，경위경검사학진위활동성소화성궤양병차Hp검사위양성적환자진행연구。대입선환자분위서관치료조여표준치료조량조，균요구오미랍서반전복，항생소반후복，공10 d。정약4주후재행위경검사혹13C뇨소호기시험이관료효，대량조적근제솔균안의향성치료분석（ITT），통계학분석채용SPSS 20.0의학통계연건진행자2검험비교。결과：Hp근제솔비교：서관치료조Hp근제솔위95.16%，10 d표준치료조근제솔위81.53%，서관치료조적근제솔고우표준치료조，차이유통계학의의（P<0.05）；재연구기간량조균무상소화도대출혈등엄중불량반응발생。량조부반응발생솔분별위10/62（16.13%）、10/65（15.38%），차이무통계학의의（P>0.05）。결론：연구표명，항유문라간균치료10 d서관요법우우표준삼련요법，구유교고적Hp근제솔。
Objective:To observe the 10 day sequential therapy with 10 days of standard therapy against H.pylori efficacy,to find new anti-Helicobacter pylori.Method:127 patients with active peptic ulcer diagnosed by endoscopy and Hp checks positive patients were studied from May 2010 to April 2012 in our hospital Gastroenterology hospitalization or outpatient treatment.Enrolled patients were divided into two groups:the sequential treatment group and standard therapy group,omeprazole meals were served,the antibiotic after meals,for a total of 10 days.Discontinued 4 weeks and then underwent endoscopy or 13C urea breath test in order to observe the efficacy,the eradication rates of the two groups by intention to treat analysis(ITT), statistical analyzes were performed using SPSS 20.0 statistical software of Medicine conducted a test to compare.Result:Hp eradication rate comparison:the incidence of side effects of Hp eradication rate of sequential therapy group(95.16%),the eradication rate of the 10d standard treatment group(81.53%), the eradication rate of sequential therapy group was higher than the 10d standard treatment group,the difference was statistically significant(P<0.05);comparison:during the study period,the sequential treatment group and 10 d standard treatment group had no upper gastrointestinal bleeding and other serious adverse reactions.Two groups incidence of side effects were 10/62(16.13%),10/65(15.38%),two sets of side effects were obvious difference was not statistically significant(P>0.05).Conclusion:This study showed that the anti-Helicobacter pylori therapy 10 d sequential therapy superior to standard triple therapy,has a higher rate of Hp eradication,whether from a course of treatment,the side effects or the economic load will display its advantages.
