CAJ | 학술논문

背景：与骨髓移植相比较，外周血干细胞移植有其自身的优点，外周血中干细胞资源多、收集方便易行、无需麻醉、创伤小、易被患者接受、安全性高、患者的造血系统易恢复等。 　　目的：观察自体外周血单个核细胞对失代偿期肝硬化患者的治疗作用及安全性。 　　方法：选择2010年11月至2011年7月于大连医科大学附属第一医院住院的4例失代偿期肝硬化患者，其中乙型肝炎后失代偿期肝硬化3例，自身免疫性肝病后失代偿期肝硬化1例，年龄31-67岁，平均年龄44岁。经粒细胞集落刺激因子动员后采集外周血干细胞，行肝动脉插管自体外周血单个核细胞移植治疗。 　　结果与结论：外周血单个核细胞采集、肝动脉内干细胞移植过程中及移植后无发热、出血、恶心等不良反应发生，行自体外周血单个核细胞移植第1，3，6个月后，纳差、乏力、食欲、腹胀等临床症状得到不同程度的改善。实验室检测肝功能和肝纤维化指标得到一定程度的改善。
배경：여골수이식상비교，외주혈간세포이식유기자신적우점，외주혈중간세포자원다、수집방편역행、무수마취、창상소、역피환자접수、안전성고、환자적조혈계통역회복등。 　　목적：관찰자체외주혈단개핵세포대실대상기간경화환자적치료작용급안전성。 　　방법：선택2010년11월지2011년7월우대련의과대학부속제일의원주원적4례실대상기간경화환자，기중을형간염후실대상기간경화3례，자신면역성간병후실대상기간경화1례，년령31-67세，평균년령44세。경립세포집락자격인자동원후채집외주혈간세포，행간동맥삽관자체외주혈단개핵세포이식치료。 　　결과여결론：외주혈단개핵세포채집、간동맥내간세포이식과정중급이식후무발열、출혈、악심등불량반응발생，행자체외주혈단개핵세포이식제1，3，6개월후，납차、핍력、식욕、복창등림상증상득도불동정도적개선。실험실검측간공능화간섬유화지표득도일정정도적개선。
BACKGROUND:Compared with bone marrow transplantation, peripheral blood stem cel transplantation has its own advantages, including rich resources of stem cel s from the peripheral blood, convenient and easy col ection, without anesthesia, smal trauma, easily accepted, high safety, and easy to restore the patient’s hematopoietic system. OBJECTIVE:To observe the function and safety of autologous peripheral blood mononuclear cel s in the treatment of patients with decompensated cirrhosis. METHODS:Four patients with decompensated liver cirrhosis were selected from November 2010 to July 2011 in the First Affiliated Hospital of Dalian Medical University, aged 31-67 (averagely 44 years). Among them, three cases had hepatitis B, and another one had autoimmune liver disease. Peripheral blood stem cel s were col ected after being mobilized by granulocyte colony stimulating factor. Then, autologous peripheral blood stem cel s were transplanted via a hepatic artery catheter. RESULTS AND CONCLUSION:There were no adverse reactions such as fever, bleeding and nausea after peripheral blood stem cel col ection and hepatic artery transplantation. Symptoms such as fatigue, poor appetite and abdominal distension gradual y improved at 1, 3 and 6 months after transplantation. Liver function and liver fibrosis indexes were improved to some extent after transplantation.