中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2013年
37期
6664-6670
,共7页
谢周通%徐皓%陈建梅%刘建建
謝週通%徐皓%陳建梅%劉建建
사주통%서호%진건매%류건건
组织构建%组织构建综述%脊髓损伤%胶质瘢痕%淋巴细胞%免疫炎症反应%星形胶质细胞%小胶质细胞%胶质纤维酸性蛋白%硫酸软骨素蛋白聚糖
組織構建%組織構建綜述%脊髓損傷%膠質瘢痕%淋巴細胞%免疫炎癥反應%星形膠質細胞%小膠質細胞%膠質纖維痠性蛋白%硫痠軟骨素蛋白聚糖
조직구건%조직구건종술%척수손상%효질반흔%림파세포%면역염증반응%성형효질세포%소효질세포%효질섬유산성단백%류산연골소단백취당
背景：胶质瘢痕是中枢神经系统再生的主要障碍，对中枢神经的再生起着物理和化学屏障的作用，如何有效抑制胶质瘢痕形成，促进神经轴突再生，具有重要意义。<br> 目的：探讨免疫反应在脊髓损伤后胶质瘢痕的形成过程中的作用。<br> 方法：通过计算机分别检索PubMed数据库和中国期刊全文数据库1990年1月至2013年1月与脊髓损伤机制、免疫细胞和脊髓损伤及脊髓损伤后胶质瘢痕形成相关文献。检索词“脊髓损伤，免疫，胶质瘢痕”和“spinal cord injury, immunity, glia scar”，限定文章检索的语言种类分别为中文和英文。经过筛选共保留72篇文献做进一步分析。<br> 结果与结论：脊髓损伤后自身免疫反应在其中所起到的作用仍一直备受争议。研究表明，脊髓损伤可造成机体细胞免疫和非特异性免疫功能的抑制，引起免疫功能降低，监测免疫指标，提高免疫功能，对促进脊髓损伤患者全面康复具有重要意义。胶质瘢痕是阻碍脊髓损伤后修复的最重要的因素。免疫炎症反应是脊髓损伤后继发加重的重要因素。脊髓损伤后的修复程度主要依赖于对残余神经元的保护,使其免受二次损伤，自身免疫性T细胞可以保护残余神经元，T 淋巴细胞在脊髓损伤后胶质瘢痕形成中的具体作用还不清楚，需要进一步探索。
揹景：膠質瘢痕是中樞神經繫統再生的主要障礙，對中樞神經的再生起著物理和化學屏障的作用，如何有效抑製膠質瘢痕形成，促進神經軸突再生，具有重要意義。<br> 目的：探討免疫反應在脊髓損傷後膠質瘢痕的形成過程中的作用。<br> 方法：通過計算機分彆檢索PubMed數據庫和中國期刊全文數據庫1990年1月至2013年1月與脊髓損傷機製、免疫細胞和脊髓損傷及脊髓損傷後膠質瘢痕形成相關文獻。檢索詞“脊髓損傷，免疫，膠質瘢痕”和“spinal cord injury, immunity, glia scar”，限定文章檢索的語言種類分彆為中文和英文。經過篩選共保留72篇文獻做進一步分析。<br> 結果與結論：脊髓損傷後自身免疫反應在其中所起到的作用仍一直備受爭議。研究錶明，脊髓損傷可造成機體細胞免疫和非特異性免疫功能的抑製，引起免疫功能降低，鑑測免疫指標，提高免疫功能，對促進脊髓損傷患者全麵康複具有重要意義。膠質瘢痕是阻礙脊髓損傷後脩複的最重要的因素。免疫炎癥反應是脊髓損傷後繼髮加重的重要因素。脊髓損傷後的脩複程度主要依賴于對殘餘神經元的保護,使其免受二次損傷，自身免疫性T細胞可以保護殘餘神經元，T 淋巴細胞在脊髓損傷後膠質瘢痕形成中的具體作用還不清楚，需要進一步探索。
배경：효질반흔시중추신경계통재생적주요장애，대중추신경적재생기착물리화화학병장적작용，여하유효억제효질반흔형성，촉진신경축돌재생，구유중요의의。<br> 목적：탐토면역반응재척수손상후효질반흔적형성과정중적작용。<br> 방법：통과계산궤분별검색PubMed수거고화중국기간전문수거고1990년1월지2013년1월여척수손상궤제、면역세포화척수손상급척수손상후효질반흔형성상관문헌。검색사“척수손상，면역，효질반흔”화“spinal cord injury, immunity, glia scar”，한정문장검색적어언충류분별위중문화영문。경과사선공보류72편문헌주진일보분석。<br> 결과여결론：척수손상후자신면역반응재기중소기도적작용잉일직비수쟁의。연구표명，척수손상가조성궤체세포면역화비특이성면역공능적억제，인기면역공능강저，감측면역지표，제고면역공능，대촉진척수손상환자전면강복구유중요의의。효질반흔시조애척수손상후수복적최중요적인소。면역염증반응시척수손상후계발가중적중요인소。척수손상후적수복정도주요의뢰우대잔여신경원적보호,사기면수이차손상，자신면역성T세포가이보호잔여신경원，T 림파세포재척수손상후효질반흔형성중적구체작용환불청초，수요진일보탐색。
BACKGROUND:The glial scar is a major obstacle to the regeneration of the central nervous system, which plays a physical and chemical barrier role to central nervous system regeneration. How to effectively inhibit glial scar formation and promote axonal regeneration has great significance. <br> OBJECTIVE:To explore the effect of the immune response in the formation of the glial scar after spinal cord injury. <br> METHODS:A computer-based online search was performed in the PubMed database and the CNKI database for the articles on the mechanisms of spinal cord injury, immune cel s and spinal cord injury as wel as the glial scar formation after spinal cord injury from January 1990 to January 2013. The key words were “spinal cord injury, immunity, glia scar”in Chinese and English. The languages of the articles were limited in Chinese and English. Final y, 72 articles were included for the further analysis according the inclusion criteria. <br> RESULTS AND CONCLUSION: After spinal cord injury, the effect of autoimmune response in which stil been much debated. Studies showed that spinal cord injury can cause suppression of cel ular immunity and non-specific immune function, causing immune function decreasing. Monitoring immune indicators and improving immune function have great significance in promoting the ful rehabilitation of patients with spinal cord injury. Glial scar is the most important factor to prevent the repairing after spinal cord injury. Immune and inflammatory response is the main reason to secondary spinal cord injury. Degree of repair after spinal cord injury mainly depends on the protection of the residual neurons in order to keep them off secondary damage. However, autoimmune T cel s can protect the residual neurons, the specific effect of T lymphocytes in glial scar formation after spinal cord injury is stil unclear, and further exploration is needed.
