CAJ | 학술논문

背景：组织工程技术的发展为已退变椎间盘功能的恢复提供了可能。 　　目的：综述椎间盘组织工程中支架的研究进展。 　　方法：由第一作者检索PubMed 数据库中1990-01-01/2012-12-31有关椎间盘组织工程中支架的文献，以“tissue engineering, intervertebral disc, scaffold”为检索词。 　　结果与结论：支架材料是组织工程研究中的一项重要组成部分。椎间盘纤维环支架材料有3大类，包括天然生物材料、人工合成材料及复合材料。椎间盘纤维环支架材料种类繁多，各有优缺点，尚无公认的最合适的支架材料，支架材料选择仍需进一步的实验研究。纳米级生物材料是研究发展的一个必然趋势，另外，利用仿生学原理，在模拟人椎间盘组织的过程中对支架材料进行改进同样是一个发展趋势；此外，可注射型支架同样是另一个研究热点，可注射型支架材料的选择范围主要集中在壳聚糖、Ⅱ型胶原、透明质酸、纤维蛋白、弹性蛋白、藻酸盐身上，目前将壳聚糖作为支架的研究相对较多。
배경：조직공정기술적발전위이퇴변추간반공능적회복제공료가능。 　　목적：종술추간반조직공정중지가적연구진전。 　　방법：유제일작자검색PubMed 수거고중1990-01-01/2012-12-31유관추간반조직공정중지가적문헌，이“tissue engineering, intervertebral disc, scaffold”위검색사。 　　결과여결론：지가재료시조직공정연구중적일항중요조성부분。추간반섬유배지가재료유3대류，포괄천연생물재료、인공합성재료급복합재료。추간반섬유배지가재료충류번다，각유우결점，상무공인적최합괄적지가재료，지가재료선택잉수진일보적실험연구。납미급생물재료시연구발전적일개필연추세，령외，이용방생학원리，재모의인추간반조직적과정중대지가재료진행개진동양시일개발전추세；차외，가주사형지가동양시령일개연구열점，가주사형지가재료적선택범위주요집중재각취당、Ⅱ형효원、투명질산、섬유단백、탄성단백、조산염신상，목전장각취당작위지가적연구상대교다。
BACKGROUND:Advancement in bioengineering based upon tissue engineering techniques may offer the possibility of repairing degenerative intervertebral disc. OBJECTIVE:To summarize the research progress in the scaffolds of tissue engineered intervertebral disc. METHODS:A computer-based retrieval was performed to search manuscripts describing tissue engineered intervertebral disc scaffolds published between January 1st, 1900 and December 31st, 2012 in PubMed database with the key words of“tissue engineering, intervertebral disc, scaffold”in English. RESULTS AND CONCLUSION:Scaffold is an important part of tissue-engineered research. There are three kinds of materials for intervertebral disc scaffolds:natural biomaterials, synthetic materials, and composite materials. A variety of scaffold materials have their own advantages and disadvantages. Up to now, none of these scaffold materials is accepted as the most suitable one. The selection of scaffold materials is stil to be further studied. The study and development of nanoscale biomaterials is an inevitable trend. Otherwise, with the help of bionics, improving scaffolds is also an inexorable trend in progress of simulating human intervertebral disc. Furthermore, injectable scaffold is also an research hot spot, and the selection range of injectable scaffold materials mainly focuses on chitosan, typeⅡcolagen,hyaluronic acid,fibrin,elastin,and alginate.C urrently, studies on chitosan as a scaffold material are relatively more.