CAJ | 학술논문

背景：交联剂是支撑分子印迹聚合物骨架的主要单元，分子印迹聚合物是否生物友好与交联剂的性能密不可分，但目前常用交联剂的生物相容性和生物降解性还不明确。 　　目的：制备新型生物可降解分子印迹聚合物，分析其吸附性能和可降解性能。 　　方法：以丙烯酰化的聚ε-己内酯为交联剂，以丙烯酸为功能单体，采用紫外光引发聚合法制备茶碱分子印迹聚合物，通过等温吸附、Scatchard分析和动力学曲线研究其吸附能力，在模拟人体生理环境体系中进行体外降解实验。 　　结果与结论：等温吸附曲线表明茶碱分子印迹聚合物和非分子印迹聚合物对模板分子茶碱均有吸附能力，但茶碱分子印迹聚合物的吸附量显著高于非分子印迹聚合物。茶碱分子印迹聚合物对茶碱的载药量为1.54%，包封率为12.48%，茶碱分子印迹聚合物和聚ε-己内酯二醇在观察时间内的体外降解率分别为6.60%和1.33%。制备的分子印迹聚合物不仅对目标分子有特异的吸附性能，而且具有良好的生物降解性能，可在模拟人体环境中进行降解。
배경：교련제시지탱분자인적취합물골가적주요단원，분자인적취합물시부생물우호여교련제적성능밀불가분，단목전상용교련제적생물상용성화생물강해성환불명학。 　　목적：제비신형생물가강해분자인적취합물，분석기흡부성능화가강해성능。 　　방법：이병희선화적취ε-기내지위교련제，이병희산위공능단체，채용자외광인발취합법제비다감분자인적취합물，통과등온흡부、Scatchard분석화동역학곡선연구기흡부능력，재모의인체생리배경체계중진행체외강해실험。 　　결과여결론：등온흡부곡선표명다감분자인적취합물화비분자인적취합물대모판분자다감균유흡부능력，단다감분자인적취합물적흡부량현저고우비분자인적취합물。다감분자인적취합물대다감적재약량위1.54%，포봉솔위12.48%，다감분자인적취합물화취ε-기내지이순재관찰시간내적체외강해솔분별위6.60%화1.33%。제비적분자인적취합물불부대목표분자유특이적흡부성능，이차구유량호적생물강해성능，가재모의인체배경중진행강해。
BACKGROUND:The cross-linking reagent is the main unit to support the skeleton of molecularly imprinted polymers, which is closely related to the bio-friendly adaption of polymers. The biocompatible and biodegradable capacities of common crosslinking agents are unclear. OBJECTIVE:To prepare a novel biodegradable molecularly imprinted polymer and to evaluate the adsorption and biodegradability properties of the polymer. METHODS:The biodegradable molecularly imprinted polymer was synthesized with the acrylated polyε-caprolactone as the cross-linking reagent under the UV polymerization. The adsorption of the polymer was evaluated by adsorption isotherm, Scatchard analysis and kinetic curves. The biodegradation of the polymer was observed in the simulated physiological environment system in vitro. RESULTS AND CONCLUSION:Both the molecularly imprinted polymer and non-molecularly imprinted polymer showed an adsorption effect on theophyl ine, the template. But the adsorption amount of the molecularly imprinted polymer was significantly more than that of the non-molecularly imprinted polymer. The drug loading and encapsulation efficiency of the molecularly imprinted polymer were 1.54%and 12.48%, respectively. The degradation rates of molecularly imprinted polymer and poly(ε-caprolactone) diol were 6.60%and 1.33%, respectively, within the observation time in vitro. The obtained molecularly imprinted polymer not only exhibited specific adsorption to certain molecules but also showed good biodegradable properties in the simulated physiological environment system, which is necessary to be a potent drug carrier.