CAJ | 학술논문

目的：探讨视网膜母细胞瘤化疗减容加局部治疗后瘤体的消退类型及预后。方法回顾性病例研究。63例(93眼)视网膜母细胞瘤患者在经过化疗减容加局部治疗后的消退类型进行回顾性分析。结果138个视网膜母细胞瘤体消退类型分为五型：0型(n=3)，1型(n=19)，2型(n=6)，3型(n=35)，4型(n=75)。肿瘤初始厚度小于或等于3mm的消退类型多为4型(84.21%)，初始厚度在3~8mm的肿瘤多为3型(34.43%)和4型(40.98%)，初始厚度大于8mm的肿瘤多为1型(35.00%)和3型(50.00%)。在黄斑区的瘤体中常见3型(45.10％)和4型(33.33％)消退类型，在黄斑区-赤道部和赤道部-锯齿缘区的瘤体中常见4型消退类型(54.35％，80.48％)。138个瘤体中其中有14个(10.14%)瘤体复发，其中有2个为0型瘤体，3个为1型瘤体，1个为2型瘤体，8个为3型瘤体。结论化疗减容加局部治疗后4型及3型消退类型最常见。多数小的瘤体转为萎缩瘢痕，中间大小的瘤体多转为萎缩瘢痕或部分钙化残留，大的瘤体多转为完全或部分钙化残留。3型消退类型的瘤体可能易复发。
목적：탐토시망막모세포류화료감용가국부치료후류체적소퇴류형급예후。방법회고성병례연구。63례(93안)시망막모세포류환자재경과화료감용가국부치료후적소퇴류형진행회고성분석。결과138개시망막모세포류체소퇴류형분위오형：0형(n=3)，1형(n=19)，2형(n=6)，3형(n=35)，4형(n=75)。종류초시후도소우혹등우3mm적소퇴류형다위4형(84.21%)，초시후도재3~8mm적종류다위3형(34.43%)화4형(40.98%)，초시후도대우8mm적종류다위1형(35.00%)화3형(50.00%)。재황반구적류체중상견3형(45.10％)화4형(33.33％)소퇴류형，재황반구-적도부화적도부-거치연구적류체중상견4형소퇴류형(54.35％，80.48％)。138개류체중기중유14개(10.14%)류체복발，기중유2개위0형류체，3개위1형류체，1개위2형류체，8개위3형류체。결론화료감용가국부치료후4형급3형소퇴류형최상견。다수소적류체전위위축반흔，중간대소적류체다전위위축반흔혹부분개화잔류，대적류체다전위완전혹부분개화잔류。3형소퇴류형적류체가능역복발。
Objective To evaluate retinoblastoma regression patterns following chemoreduction and adjuvant therapy. Methods Retrospective case series. the regression patterns following chemoreduction and adjuvant therapy of 63 cases (93 eyes) of retinoblastoma patients were researched. Results Retinoblastoma regressions were type 0 (n=3),type 1 (n=19),type 2 (n=6),type 3 (n=35),and type4 (n=75). Tumors with an initial thickness of 3 mm or less regressed most often to type 4 (84.21%),those 3 to 8 mm regressed to type 3(34.43%) or type 4 (40.98%),and those thicker than 8 mm regressed to type 1 (35.00%) or type 3 (50.00%). Tumors in the macular area most often to type 3 (45.10%) or type 4 (33.33%),and those in the macular to equator area and the equator to ora serrata region most often to type 4 (54.35%,80.48%). 14 tumors recurred,2 tumors were type 0,3 tumors were type 1,1 tumor was type 2 and 8 tumors were type 3. Conclusions Following chemoreduction,type 4 and type 3 regression patterns were most common. Following chemoreduction,most small retinoblastomas result in a flat scar,intermediate tumors in a flat or partially calcified remnant,and large tumors in a more completely calcified remnant. Tumor recurrence was usually found fol-lowing regression pattern type 3.