CAJ | 학술논문

目的：采用图形视觉诱发电位平均峰的潜伏期和波幅的变化为指标，评估使用氟西汀治疗形觉剥夺型弱视模型猫的疗效。方法采用德国Roland视觉电生理仪，对3例正常对照组和15例形觉剥夺型弱视猫进行P-VEP的检测，进行治疗前后潜伏期和波幅的比较。结果1、正常对照组P波潜伏期平均48.33±3.51ms，波幅平均55.69±3.52μV，单眼形觉剥夺猫P波的潜伏期平均58.23±4.62ms，波幅平均38.24±2.96μV，与正常组相比有统计学意义(孕<0.05)。2、经氟西汀治疗4周、8周后，P波潜伏期稍缩短，波幅稍增加，与未经治疗的对照组比较无统计学意义。治疗12周后，P波潜伏期进一步缩短，波幅进一步增加，与未经治疗的对照组相比较有统计学意义，但仍低于正常对照组。治疗16周、20周后，P波潜伏期及波幅进一步恢复，与正常对照相比，未见因形觉剥夺而引起的明显变化，无统计学意义。结论经氟西汀治疗16周或更长时间后，弱视模型猫的视觉诱发电位P波潜伏期缩短，波幅增加，其变化过程与人类弱视儿童治愈过程中视觉诱发电位P波潜伏期和波幅的变化相一致。
목적：채용도형시각유발전위평균봉적잠복기화파폭적변화위지표，평고사용불서정치료형각박탈형약시모형묘적료효。방법채용덕국Roland시각전생리의，대3례정상대조조화15례형각박탈형약시묘진행P-VEP적검측，진행치료전후잠복기화파폭적비교。결과1、정상대조조P파잠복기평균48.33±3.51ms，파폭평균55.69±3.52μV，단안형각박탈묘P파적잠복기평균58.23±4.62ms，파폭평균38.24±2.96μV，여정상조상비유통계학의의(잉<0.05)。2、경불서정치료4주、8주후，P파잠복기초축단，파폭초증가，여미경치료적대조조비교무통계학의의。치료12주후，P파잠복기진일보축단，파폭진일보증가，여미경치료적대조조상비교유통계학의의，단잉저우정상대조조。치료16주、20주후，P파잠복기급파폭진일보회복，여정상대조상비，미견인형각박탈이인기적명현변화，무통계학의의。결론경불서정치료16주혹경장시간후，약시모형묘적시각유발전위P파잠복기축단，파폭증가，기변화과정여인류약시인동치유과정중시각유발전위P파잠복기화파폭적변화상일치。
Objective To study the influence of fluezetine on changes of PVEP in the monocular visual de-privation cats. Methods The P-VEP of fifteen monocular visual deprivation cats were recorded with Roland P-VEP e-quipments. The changes between before- and after-treatment with fluezetine for groups of different periods (4, 8, 12, 16 and 20 weeks)were investigated by comparing the monocular visual deprivation cats with the normal group of animals. Results 1、The average amplitude density was 55.69±3.52μV, and the average latency was 48.33±3.51ms in the group of normal cats. The average amplitude density was 38.24±2.96μV, and the average latency was 58.23±4.62ms in the group of the monocular visual deprivation cats. 2、After treatment of fluezetine for twelve weeks, the amplitude densties were increased progressively and the latencies were shortened than before-treatment. The amplitude densities and the latencies partially have been recovered after treatment for sixteen and twenty weeks, but there is no statistically signifi-cant by comparison with normal group. Conclusions Fluoxetine could increase the amplitude densities, and shorten the latencies as well in the monocular visual deprivation cats. The results were corresponded to those of clinic theurapia for amblyopia’s children using fluoxetine.