国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2014年
9期
1134-1135,1137
,共3页
心肌梗死%肌红蛋白%肌钙蛋白T%利钠肽 ,脑%诊断
心肌梗死%肌紅蛋白%肌鈣蛋白T%利鈉肽 ,腦%診斷
심기경사%기홍단백%기개단백T%리납태 ,뇌%진단
myocardial infarction%myoglobin%troponin T%natriuretic peptide,brain%diagnosis
目的：探讨血清心肌肌钙蛋白T（cTnT）、血浆氨基末端B型利钠肽前体（NT-proBNP）和肌红蛋白（Myo）联合检测在急性心肌梗死（AMI）诊断中的临床价值。方法选择以急性胸痛为主要症状的患者440例，将其分为AMI组和非AMI组，将220例健康者作为对照组。采用BECKMAN COULTER Access 2全自动微粒子化学发光免疫分析仪检测其血清 NT-proBNP、cTnT及Myo浓度。结果 AMI组患者血清 NT-proBNP、cTnT 和 Myo 浓度分别为（3546．12±220．95） pg/mL、（0．13 ± 0．02）μg/L和（88．12±14．27）μg/L ，显著高于非AMI组和对照组（P＜0．05）。NT-proBNP、cTnT 和Myo检测的受试者工作特征（ROC）曲线的曲线下面积（AUC）分别为0．809、0．851和0．749，cTnT检测的ROC曲线AUC显著高于Myo（P＜0．05）。NT-proBNP、cTnT及Myo联合检测的敏感性、特异性及诊断符合率分别为0．957、0．950及0．948，显著高于2种指标的联合检测（P＜0．05）。结论血清NT-proBNP、cTnT和Myo联合检测能有效提高AMI诊断的敏感性、特异性及诊断符合率。
目的：探討血清心肌肌鈣蛋白T（cTnT）、血漿氨基末耑B型利鈉肽前體（NT-proBNP）和肌紅蛋白（Myo）聯閤檢測在急性心肌梗死（AMI）診斷中的臨床價值。方法選擇以急性胸痛為主要癥狀的患者440例，將其分為AMI組和非AMI組，將220例健康者作為對照組。採用BECKMAN COULTER Access 2全自動微粒子化學髮光免疫分析儀檢測其血清 NT-proBNP、cTnT及Myo濃度。結果 AMI組患者血清 NT-proBNP、cTnT 和 Myo 濃度分彆為（3546．12±220．95） pg/mL、（0．13 ± 0．02）μg/L和（88．12±14．27）μg/L ，顯著高于非AMI組和對照組（P＜0．05）。NT-proBNP、cTnT 和Myo檢測的受試者工作特徵（ROC）麯線的麯線下麵積（AUC）分彆為0．809、0．851和0．749，cTnT檢測的ROC麯線AUC顯著高于Myo（P＜0．05）。NT-proBNP、cTnT及Myo聯閤檢測的敏感性、特異性及診斷符閤率分彆為0．957、0．950及0．948，顯著高于2種指標的聯閤檢測（P＜0．05）。結論血清NT-proBNP、cTnT和Myo聯閤檢測能有效提高AMI診斷的敏感性、特異性及診斷符閤率。
목적：탐토혈청심기기개단백T（cTnT）、혈장안기말단B형리납태전체（NT-proBNP）화기홍단백（Myo）연합검측재급성심기경사（AMI）진단중적림상개치。방법선택이급성흉통위주요증상적환자440례，장기분위AMI조화비AMI조，장220례건강자작위대조조。채용BECKMAN COULTER Access 2전자동미입자화학발광면역분석의검측기혈청 NT-proBNP、cTnT급Myo농도。결과 AMI조환자혈청 NT-proBNP、cTnT 화 Myo 농도분별위（3546．12±220．95） pg/mL、（0．13 ± 0．02）μg/L화（88．12±14．27）μg/L ，현저고우비AMI조화대조조（P＜0．05）。NT-proBNP、cTnT 화Myo검측적수시자공작특정（ROC）곡선적곡선하면적（AUC）분별위0．809、0．851화0．749，cTnT검측적ROC곡선AUC현저고우Myo（P＜0．05）。NT-proBNP、cTnT급Myo연합검측적민감성、특이성급진단부합솔분별위0．957、0．950급0．948，현저고우2충지표적연합검측（P＜0．05）。결론혈청NT-proBNP、cTnT화Myo연합검측능유효제고AMI진단적민감성、특이성급진단부합솔。
Objective To investigate the clinical significance of combined detection of serum cardiac troponin T (cTnT ) ,N-termi-nal pro-B-type natriuretic peptide(NT-proBNP) and myoglobin(Myo) in acute myocardial infarction diagnosis .Methods 440 pa-tients with main symptoms of acute chest pain were enrolled and divided into AMI group and non-AMI group ,and 220 healthy peo-ple were served as the control group .BECKMAN COULTER Access 2 automated chemiluminescent microparticle immunoassay analyzer was employed to detect their serum NT-proBNP ,cTnT and Myo concentrations .Results The serum concentrations of NT-proBNP ,cTnT and Myo of patients with AMI were (3 546 .12 ± 220 .95) pg/mL ,(0 .13 ± 0 .02)μg/L and (88 .12 ± 14 .27)μg/L , respectively ,which were significantly higher than those in non-AMI group and the control group(P<0 .05) .Areas under the curve (AUC) of receiver operator characteristic(ROC) of NT-proBNP ,cTnT and Myo detection were 0 .809 ,0 .851 and 0 .749 ,respec-tively ,and the ROC curve AUC of cTnT detection was markedly higher than that of Myo (P<0 .05) .The sensitivity ,specificity and diagnostic accuracy of combined detection of NT-proBNP ,cTnT and Myo were 0 .957 ,0 .950 and 0 .948 ,respectively ,which was significantly higher than those in combined detection of any two kinds of indicators (P<0 .05) .Conclusion Combined detection of serum NT-proBNP ,cTnT and Myo can improve the sensitivity ,specificity and diagnostic accuracy in AMI diagnosis .
