CAJ | 학술논문

目的：总结儿童视神经炎（ON）的临床特点和预后。方法：回顾性分析2007年1月至2013年1月我院确诊为 ON 的患儿共31例（52眼）的临床资料及随访结果，比较不同临床特征对 ON 转化为多发性硬化（MS）或视神经脊髓炎（NMO）的影响。结果：10例（32.3%）病前1~3周有上呼吸道感染史，21例（67.7%）双眼起病，初诊视力下降至≤0.1共29眼（55.8%），13例（41.9%）出现视乳头炎；治疗后视力恢复至逸1.0者共21眼（40.4%）。平均随访时间为43.6月（12~84月），9例（29.0%）在随访期间转化为 MS 或 NMO，其中6例诊断为 MS，3例诊断为 NMO。2组复发比例差异有统计学意义（=0.015）。结论：儿童 ON 双眼起病多见，视力下降严重，治疗后恢复良好。
목적：총결인동시신경염（ON）적림상특점화예후。방법：회고성분석2007년1월지2013년1월아원학진위 ON 적환인공31례（52안）적림상자료급수방결과，비교불동림상특정대 ON 전화위다발성경화（MS）혹시신경척수염（NMO）적영향。결과：10례（32.3%）병전1~3주유상호흡도감염사，21례（67.7%）쌍안기병，초진시력하강지≤0.1공29안（55.8%），13례（41.9%）출현시유두염；치료후시력회복지일1.0자공21안（40.4%）。평균수방시간위43.6월（12~84월），9례（29.0%）재수방기간전화위 MS 혹 NMO，기중6례진단위 MS，3례진단위 NMO。2조복발비례차이유통계학의의（=0.015）。결론：인동 ON 쌍안기병다견，시력하강엄중，치료후회복량호。
Objective To outline the clinical characteristics and prognosis of children optic neuritis (ON). Methods: Thirty-one children (52 eyes) who were diagnosed as ON at Tongji Hospital from January 2007 to January 2013 were retrospectively analyzed. The different clinical characteristics which could affect transformation of ON into multiple sclerosis (MS) or neuromyelitis optica (NMO) were compared. Results: An upper respiration tract infection 1~3 weeks prior to onset of ON was reported in 10 patients (32.3%). Bilateral involvement was presented in 21 patients (67.7%). 29 eyes (55.8%) had visual acuity of 0.1 or less at onset and papillitis was evident in 13 patients (41.9%). Visual acuity better than 1.0 after treatment was reported up to 21 eyes (40.4%). Average follow-up time was 43.6 months (12~84 months) and nine patients (29.0%) had converted into MS (6 cases) or NMO (3 cases) in this observation. There was significant difference of the recurrence rate in 2 groups ( =0.015). Conclusion: Optic neuritis in childhood is more likely to be bilateral with severe vision loss, but the visual prognosis is relatively good after treatment.