CAJ | 학술논문

目的：探讨急性脑梗死患者脑白质疏松（LA）与血尿酸(UA)的关系。方法选择急性脑梗死患者97例，以头MRI-T2加权像评估是否有白质损害，其中有白质病变(AL)组59例，无白质病变(非LA)组38例。于48 h内进行抽血检验血尿酸水平，并分别以胆碱能通路高信号评分量表（CHIPS评分）及改良Scheltens量表对LA组进行评分。观察2组UA水平差异及UA与LA组脑白质疏松评分的关系。结果 LA组血尿酸含量(356.42±81.18)μmol/L，高于非LA组(292.97±95.98)μmol/L，2组差异有统计学意义(P<0.01)。血尿酸与CHIPS评分呈显著正相关（P<0.01），与Scheltens评分呈显著正相关（P<0.01）。结论血尿酸水平与急性脑梗死患者的脑白质疏松有关，血尿酸水平越高，脑白质疏松程度越重。
목적：탐토급성뇌경사환자뇌백질소송（LA）여혈뇨산(UA)적관계。방법선택급성뇌경사환자97례，이두MRI-T2가권상평고시부유백질손해，기중유백질병변(AL)조59례，무백질병변(비LA)조38례。우48 h내진행추혈검험혈뇨산수평，병분별이담감능통로고신호평분량표（CHIPS평분）급개량Scheltens량표대LA조진행평분。관찰2조UA수평차이급UA여LA조뇌백질소송평분적관계。결과 LA조혈뇨산함량(356.42±81.18)μmol/L，고우비LA조(292.97±95.98)μmol/L，2조차이유통계학의의(P<0.01)。혈뇨산여CHIPS평분정현저정상관（P<0.01），여Scheltens평분정현저정상관（P<0.01）。결론혈뇨산수평여급성뇌경사환자적뇌백질소송유관，혈뇨산수평월고，뇌백질소송정도월중。
Objective To investigate the relationship of leukoaraiosis and the serum uric acid in patients with acute cerebral infarction. Methods 97 patients with acute cerebral infarction are selected as a case.All cases were divided into group LA(LA,59 cases)and group NLA(non-LA,38 cases)according to the cranial MRI-T 2 scanning. They are all examined by blood test within 48 hours. The assessments by cholinergic pathways hyperintensities scale (CHIPS) and Scheltens scale were performed in patients undergoing cranial MRI-T 2 scanning. Observe the different of the levels of the serum uric acid between group LA and group NLA.A correlation analysis was performed between the serum uric acid and the score. Results The serum UA level of group LA(356.42±81.18)μmol/L was signiifcantly higher than group NLA(292.97±95.98)μmol/L. There was signiifcant positive correlation between serum UA level and CHIPS score;There was signiifcant positive correlation between serum UA level and Scheltens scale score. Conclusion In acute cerebral infarction patients LA is probably related to the serum uric acid. The serum uric acid is higher, the degree of LA is severer.