中国伤残医学
中國傷殘醫學
중국상잔의학
CHINESE JOURNAL OF TRAUMA AND DISABILITY MEDICINE
2014年
9期
65-66
,共2页
米力农%去甲肾上腺素%手足口病
米力農%去甲腎上腺素%手足口病
미력농%거갑신상선소%수족구병
Milrinone%Norepinephrine%Hand-foot-mouse disease
目的：观察米力农对重症手足口病（ HFMD）患儿疗效及对血清中去甲肾上腺素（ NE）水平的影响。方法：以100例3岁以下重症手足口病患儿为研究对象，所有病例随机分为2组：对照组和米力农组，2组患儿均给予必要的对症治疗：抗感染、脱水、限制水入量、吸氧、利尿、镇静、止惊等。米力农组以0．5μg /kg-1 min-1的速度静脉滴注米力农，连续用药时长不超过72小时，病情稳定后予停用。观察2组治疗前后心率、呼吸、心输出量（ CO）、血清去甲肾上腺素变化。结果：治疗72小时后，2组的心率、呼吸降低，心输出量（ CO）升高，血清去甲肾上腺素降低，较治疗前好转，且米力农组的好转效果明显优于对照组，差异有统计学意义（P＜0．05）。结论：（1）米力农可以有效的改善重症手足口病的心率、呼吸、心输出量，并可降低去甲肾上腺素水平。（2）去甲肾上腺素在重症手足病治疗中可以起到一定评价作用。
目的：觀察米力農對重癥手足口病（ HFMD）患兒療效及對血清中去甲腎上腺素（ NE）水平的影響。方法：以100例3歲以下重癥手足口病患兒為研究對象，所有病例隨機分為2組：對照組和米力農組，2組患兒均給予必要的對癥治療：抗感染、脫水、限製水入量、吸氧、利尿、鎮靜、止驚等。米力農組以0．5μg /kg-1 min-1的速度靜脈滴註米力農，連續用藥時長不超過72小時，病情穩定後予停用。觀察2組治療前後心率、呼吸、心輸齣量（ CO）、血清去甲腎上腺素變化。結果：治療72小時後，2組的心率、呼吸降低，心輸齣量（ CO）升高，血清去甲腎上腺素降低，較治療前好轉，且米力農組的好轉效果明顯優于對照組，差異有統計學意義（P＜0．05）。結論：（1）米力農可以有效的改善重癥手足口病的心率、呼吸、心輸齣量，併可降低去甲腎上腺素水平。（2）去甲腎上腺素在重癥手足病治療中可以起到一定評價作用。
목적：관찰미력농대중증수족구병（ HFMD）환인료효급대혈청중거갑신상선소（ NE）수평적영향。방법：이100례3세이하중증수족구병환인위연구대상，소유병례수궤분위2조：대조조화미력농조，2조환인균급여필요적대증치료：항감염、탈수、한제수입량、흡양、이뇨、진정、지량등。미력농조이0．5μg /kg-1 min-1적속도정맥적주미력농，련속용약시장불초과72소시，병정은정후여정용。관찰2조치료전후심솔、호흡、심수출량（ CO）、혈청거갑신상선소변화。결과：치료72소시후，2조적심솔、호흡강저，심수출량（ CO）승고，혈청거갑신상선소강저，교치료전호전，차미력농조적호전효과명현우우대조조，차이유통계학의의（P＜0．05）。결론：（1）미력농가이유효적개선중증수족구병적심솔、호흡、심수출량，병가강저거갑신상선소수평。（2）거갑신상선소재중증수족병치료중가이기도일정평개작용。
Objective:To observe the effect of milrinone in treatment of severe hand -foot-mouse disease(HFMD) and the level of norepinephrine ( NE) in serum.Methods:100 cases of children , under 3 year's old, who were diagnosed as HFMD were selected in this study.The subjects were divided into 2 groups randomly:control group (n=50) and milrinone group (n=50).Symptomatic treatment necessary to give children hospitalized , such as anti -infection, dehydration, limiting water intake, oxygen, diuretic, sedative, control seizures, etc.Additional, a continuous infusion of 0.5μg /kg-1min-1 in milrinone group, no more than 72 h, stop after disabling con-dition stable.The changes of heart rate, respiration, cardiac output (CO), NE before and after treatment were observed .Results:72 hours after treatment , the heart rate , respiration , NE of both two groups were reduced , CO increased instead , improved before the treat-ment, and the milrinone group improved more significant than the control group , the difference was statistically significant (P<0.05). Conclusion:1 Milrinone can improve the heart rate , respiration, cardiac output in severe HFMD effectively , and reduce levels of norepi-nephrine .2 Norepinephrine may play a role in the evaluation of treatment of severe HFMD .
