CAJ | 학술논문

托法替尼为作用于细胞内酪氨酸激酶的小分子口服抑制剂，用于治疗成人甲氨喋呤反应不佳或不能耐受的中度至重度活动性类风湿性关节炎，临床可与甲氨喋呤及其他非生物类DMARDs联合使用。本文就其作用机制、药效学、药动学、相互作用、临床评价及安全性等方面进行综述。
탁법체니위작용우세포내락안산격매적소분자구복억제제，용우치료성인갑안첩령반응불가혹불능내수적중도지중도활동성류풍습성관절염，림상가여갑안첩령급기타비생물류DMARDs연합사용。본문취기작용궤제、약효학、약동학、상호작용、림상평개급안전성등방면진행종술。
Tofacitinib citrate, an inhibitor of Janus kinases (JAKs), is indicated for the treatment of adult patients with moderately to severely active rheumatoid arthritis who have had an inadequate response or intolerance to methotrexate. It may be used as monotherapy or in combination with methotrexate or other nonbiologic disease-modifying antirheumatic drugs. The mechanism, pharmacodynamics, pharmacokinetics, drug interaction, clinical evaluation and safety of tofacitinib citrate were reviewed.