CAJ | 학술논문

目的：研究注射用盐酸头孢甲肟在大输液中的热降解动力学过程，预测其热稳定性。方法采用高效液相色谱法测定头孢甲肟含量，用经典恒温法和多元线性模型两种方法计算头孢甲肟在大输液中的有效期。结果头孢甲肟在两种大输液中的热降解动力学过程符合一级动力学特征，用经典恒温法和多元线性模型预测头孢甲肟在0.9%氯化钠注射液中的有效期分别为2.20和1.52 d；在5%葡萄糖注射液中的有效期分别为2.09和1.53 d。结论头孢甲肟在0.9%氯化钠注射液和5%葡萄糖注射液中的热稳定性差，两种方法预测的有效期基本一致。
목적：연구주사용염산두포갑우재대수액중적열강해동역학과정，예측기열은정성。방법채용고효액상색보법측정두포갑우함량，용경전항온법화다원선성모형량충방법계산두포갑우재대수액중적유효기。결과두포갑우재량충대수액중적열강해동역학과정부합일급동역학특정，용경전항온법화다원선성모형예측두포갑우재0.9%록화납주사액중적유효기분별위2.20화1.52 d；재5%포도당주사액중적유효기분별위2.09화1.53 d。결론두포갑우재0.9%록화납주사액화5%포도당주사액중적열은정성차，량충방법예측적유효기기본일치。
Objective To investigate thermal degradation kinetic characteristics of Cefmenoxime Hydrochloride in infusion solutions, and predict its thermal stability. Methods The HPLC was applied to determine the contents of Cefmenoxime Hydrochloride. Classical isothermal kinetic method and multivariate linear model were used to predict the expiration date of the injection. Results It was found that the thermal degradation kinetics of Cefmenoxime Hydrochloride in two infusion solutions corresponded with the first-order kinetics. The expiration dates of Cefmenoxime Hydrochloride in 0. 9%sodium chloride injection calculated by two different methods were 2. 20 days and 1. 52 days,and in 5% glucose injection were 2. 09 days and 1. 53 days,respectively. Conclusion The thermal stability of Cefmenoxime Hydrochloride in infusion solutions is poor and its expiration dates are the same calculated by two different methods.