胃肠病学
胃腸病學
위장병학
CHINESE JOURNAL OF GASTROENTEROLOGY
2014年
5期
294-296
,共3页
娄兰明%时丽平%孙秀威
婁蘭明%時麗平%孫秀威
루란명%시려평%손수위
Raf激酶抑制蛋白%基质金属蛋白酶-9%结直肠肿瘤%信号传导
Raf激酶抑製蛋白%基質金屬蛋白酶-9%結直腸腫瘤%信號傳導
Raf격매억제단백%기질금속단백매-9%결직장종류%신호전도
Raf Kinase Inhibitor Protein%Matrix Metalloproteinase-9%Colorectal Neoplasms%Signal Transduction
Raf 激酶抑制蛋白(RKIP)是磷脂酰乙醇胺结合蛋白家族成员之一,可抑制肿瘤细胞转移,与肿瘤的发生、发展密切相关。基质金属蛋白酶-9(MMP-9)是一种能降解细胞外基质的内肽酶,在肿瘤侵袭、转移过程中发挥重要作用。本文就 RKIP 和 MMP-9在结直肠癌中的研究进展作一综述。
Raf 激酶抑製蛋白(RKIP)是燐脂酰乙醇胺結閤蛋白傢族成員之一,可抑製腫瘤細胞轉移,與腫瘤的髮生、髮展密切相關。基質金屬蛋白酶-9(MMP-9)是一種能降解細胞外基質的內肽酶,在腫瘤侵襲、轉移過程中髮揮重要作用。本文就 RKIP 和 MMP-9在結直腸癌中的研究進展作一綜述。
Raf 격매억제단백(RKIP)시린지선을순알결합단백가족성원지일,가억제종류세포전이,여종류적발생、발전밀절상관。기질금속단백매-9(MMP-9)시일충능강해세포외기질적내태매,재종류침습、전이과정중발휘중요작용。본문취 RKIP 화 MMP-9재결직장암중적연구진전작일종술。
Raf kinase inhibitor protein (RKIP)is a member of the phosphatidylethanolamine-binding protein family, which can inhibit the metastasis of tumor cells and is closely associated with the occurrence and development of tumor. Matrix metalloproteinase-9 (MMP-9)is a endopeptidase that can degrade extracellular matrix and plays an important role in invasion and metastasis of tumor.This article reviewed the advances in studies on RKIP and MMP-9 in colorectal cancer.