CAJ | 학술논문

炎症性肠病（IBD）包括克罗恩病（CD）和溃疡性结肠炎（UC），目前两者的鉴别诊断依赖临床症状、内镜检查、病理活检以及实验室和影像学检查等。近年来，IBD 相关的生物标记物检测因无创、操作简单、易被患者接受而发展迅速。此外，随着全基因组关联分析（GWAS）的开展，对 CD 和 UC 相关遗传突变位点和易感基因的研究取得了较大进展，为疾病诊断提供了新方向。本文就血清分子标记物和易感基因对 IBD 鉴别诊断的研究进展作一综述。
염증성장병（IBD）포괄극라은병（CD）화궤양성결장염（UC），목전량자적감별진단의뢰림상증상、내경검사、병리활검이급실험실화영상학검사등。근년래，IBD 상관적생물표기물검측인무창、조작간단、역피환자접수이발전신속。차외，수착전기인조관련분석（GWAS）적개전，대 CD 화 UC 상관유전돌변위점화역감기인적연구취득료교대진전，위질병진단제공료신방향。본문취혈청분자표기물화역감기인대 IBD 감별진단적연구진전작일종술。
Inflammatory bowel disease (IBD)includes Crohn’s disease (CD)and ulcerative colitis (UC).The differential diagnosis between CD and UC mainly depends on clinical symptoms,endoscopy,pathological biopsy,laboratory and imaging examinations.In recent years,studies with a variety of IBD-related biomarkers develop rapidly because of its non-invasiveness,simple and easily acceptable.With the development of genome-wide association study (GWAS),great progress has been achieved in studies of gene mutations and susceptibility genes related with CD and UC,which provides new approach for diagnosis of the disease.This article reviewed the advances in studies on serum biomarkers and susceptibility genes in differential diagnosis of IBD.