CAJ | 학술논문

目的：分析评价高尔基体蛋白73（GP73）、AFP、VEGF在原发性肝癌、癌旁组织以及正常肝脏组织中的表达及临床意义。方法取原发性肝癌组织、癌旁组织及正常肝组织，分别检测GP73、AFP、VEGF的含量。结果肝癌组织中GP73、VEGF和AFP表达最强，其次为癌旁组织，正常组织中表达最弱，三者比较，差异有统计学意义（P＜0.01）。肝癌组织中，GP73和VEGF的表达均显著高于AFP（P＜0.01）。经Pearson相关分析显示GP73和VEGF在肝癌组织中的表达水平具有相关性（r=0.271，P＜0.01）。结论 GP73、VEGF和AFP在肝癌组织中呈高表达，联合检测三者有助于原发性肝癌的诊断。
목적：분석평개고이기체단백73（GP73）、AFP、VEGF재원발성간암、암방조직이급정상간장조직중적표체급림상의의。방법취원발성간암조직、암방조직급정상간조직，분별검측GP73、AFP、VEGF적함량。결과간암조직중GP73、VEGF화AFP표체최강，기차위암방조직，정상조직중표체최약，삼자비교，차이유통계학의의（P＜0.01）。간암조직중，GP73화VEGF적표체균현저고우AFP（P＜0.01）。경Pearson상관분석현시GP73화VEGF재간암조직중적표체수평구유상관성（r=0.271，P＜0.01）。결론 GP73、VEGF화AFP재간암조직중정고표체，연합검측삼자유조우원발성간암적진단。
Objective To analyze the expression and clinical significance of Golgi protein 73 (GP73),AFP and VEGF in primary liver cancer,para-carcinoma tissues and normal liver tissues. Methods Collected primary liver cancer tissue, para-carcinoma tissue,normal liver,and detected expression of GP73,AFP and VEGF. Results GP73,AFP,VEGF in PHC tissue were highest,para-carcinoma tissue were next,normal liver tissue were lest,and there were significant difference in three groups(P<0.01). Expression of GP73 and VEGF in PHC tissue were higher than AFP(P<0.01). Expression of GP73 and VEGF showed positive correlation (r=0.271,P<0.01) in PHC tissue by Pearson correlation analysis. Conclusion GP73,VEGF and AFP show high expression in PHC tissue,and GP73,VEGF combined with AFP detection can improve diagnosis of PHC.