CAJ | 학술논문

本文对抗癌药物甲磺酸伊马替尼的多晶型与稳定性进行了分析与研究.通过X射线粉末衍射仪( XRD)测定了伊马替尼的晶型，并测定了在不同湿度下的稳定性，用X射线衍射原位高温附件( in situ high temperature)测定了伊马替尼的热稳定性.结果表明，该批次伊马替尼为α晶型，在从室温至200℃的加热过程中晶体结构稳定，在RH 75%的湿度条件下，结构也比较稳定，但在RH 92.5%的高湿度时，晶体结构逐渐向无定形转化.
본문대항암약물갑광산이마체니적다정형여은정성진행료분석여연구.통과X사선분말연사의( XRD)측정료이마체니적정형，병측정료재불동습도하적은정성，용X사선연사원위고온부건( in situ high temperature)측정료이마체니적열은정성.결과표명，해비차이마체니위α정형，재종실온지200℃적가열과정중정체결구은정，재RH 75%적습도조건하，결구야비교은정，단재RH 92.5%적고습도시，정체결구축점향무정형전화.
This article studies the stability and the crystal structure of an anticancer drug imatinib mesylate. The crystal form of the imatinib mesylate was determined by means of X-ray powder diffraction. The stability under different humidity was determined and the thermostability of imatinib mesylate was analyzed by X-ray diffraction( XRD) with in situ high temperature accessories. The results showed that the sample is the α crystalline form and its crystal form was stable during the heating process from room temperature to 200℃. The crystal form was stable under low humidity,but unstable under high humidity and finally turned to amorphous.