中国现代医生
中國現代醫生
중국현대의생
CHINA MODERN DOCTOR
2014年
14期
76-78
,共3页
结核性脑膜炎%肿瘤坏死因子-α%白细胞介素-6%白细胞介素-18
結覈性腦膜炎%腫瘤壞死因子-α%白細胞介素-6%白細胞介素-18
결핵성뇌막염%종류배사인자-α%백세포개소-6%백세포개소-18
Tuberculous meningitis%TNF-α%IL-6%IL-18
目的：观察结核性脑膜炎患者脑脊液中肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）和白细胞介素-18（IL-18）的表达特征，关注其临床价值。方法选取120例结核性脑膜炎患者作为观察组，应用ELISA检测观察组脑脊液中TNF-α、IL-6和IL-18的表达。结果观察组不同分期患者TNF-α、IL-6和IL-18的表达差异有统计学意义，观察组中TNF-α、IL-6和IL-18的表达具有相关性。结论结核性脑膜炎患者脑脊液中TNF-α、IL-6和IL-18高表达及协同性对促进患者病程的进展可能有一定价值，联合检测TNF-α、IL-6和IL-18的表达可能对判断病情程度有一定价值。
目的：觀察結覈性腦膜炎患者腦脊液中腫瘤壞死因子-α（TNF-α）、白細胞介素-6（IL-6）和白細胞介素-18（IL-18）的錶達特徵，關註其臨床價值。方法選取120例結覈性腦膜炎患者作為觀察組，應用ELISA檢測觀察組腦脊液中TNF-α、IL-6和IL-18的錶達。結果觀察組不同分期患者TNF-α、IL-6和IL-18的錶達差異有統計學意義，觀察組中TNF-α、IL-6和IL-18的錶達具有相關性。結論結覈性腦膜炎患者腦脊液中TNF-α、IL-6和IL-18高錶達及協同性對促進患者病程的進展可能有一定價值，聯閤檢測TNF-α、IL-6和IL-18的錶達可能對判斷病情程度有一定價值。
목적：관찰결핵성뇌막염환자뇌척액중종류배사인자-α（TNF-α）、백세포개소-6（IL-6）화백세포개소-18（IL-18）적표체특정，관주기림상개치。방법선취120례결핵성뇌막염환자작위관찰조，응용ELISA검측관찰조뇌척액중TNF-α、IL-6화IL-18적표체。결과관찰조불동분기환자TNF-α、IL-6화IL-18적표체차이유통계학의의，관찰조중TNF-α、IL-6화IL-18적표체구유상관성。결론결핵성뇌막염환자뇌척액중TNF-α、IL-6화IL-18고표체급협동성대촉진환자병정적진전가능유일정개치，연합검측TNF-α、IL-6화IL-18적표체가능대판단병정정도유일정개치。
Objective To dectect expressions on TNF-α, IL-6 and IL-18 of cerebrospinal fluid in patients with tuber-culous meningitis, study their clinical significance. Methods A total of 120 cases with tuberculous meningitis were col-lected as the observation group, the expressions of TNF-α, IL-6 and IL-18 were detected by ELISA method. Results The expressions of TNF-α, IL-6 and IL-18 were statistically significant in different stage. Positive relationship were found between TNF-α, IL-6 and IL-18 in observation group. Conclusion The higher expressions and synergistic effect of TNF-α, IL-6 and IL-18 can promote the progression in patients with tuberculous meningitis. The combined detec-tion of TNF-α, IL-6 and IL-18 may be important to injudge illness degree.
