中华普通外科学文献(电子版)
中華普通外科學文獻(電子版)
중화보통외과학문헌(전자판)
CHINESE JOURNAL OF GENERAL SURGERY(ELECTRONIC VERSION)
2013年
5期
393-396
,共4页
彭鹏(综述)%胡泽民(审校)
彭鵬(綜述)%鬍澤民(審校)
팽붕(종술)%호택민(심교)
肝癌缺失基因1%肝癌%肿瘤抑制基因
肝癌缺失基因1%肝癌%腫瘤抑製基因
간암결실기인1%간암%종류억제기인
DLC-1%Hepatocellular carcinoma%Tumor suppressor gene
肝癌缺失基因-1(DLC-1)是从原发性肝癌组织中分离出来的一种肿瘤抑制基因。它在人类多种恶性肿瘤中表达缺失或下调,是近年来研究比较热门的肿瘤抑制基因之一。本文将对DLC-1基因的结构及生物学功能作一介绍,结合目前关于DLC-1在肝癌中的最新研究成果,探讨DLC-1基因在肝癌发生发展中的作用机制,并对DLC-1在肝癌中表达缺失的遗传学和表观遗传学机制进行了深入讨论。
肝癌缺失基因-1(DLC-1)是從原髮性肝癌組織中分離齣來的一種腫瘤抑製基因。它在人類多種噁性腫瘤中錶達缺失或下調,是近年來研究比較熱門的腫瘤抑製基因之一。本文將對DLC-1基因的結構及生物學功能作一介紹,結閤目前關于DLC-1在肝癌中的最新研究成果,探討DLC-1基因在肝癌髮生髮展中的作用機製,併對DLC-1在肝癌中錶達缺失的遺傳學和錶觀遺傳學機製進行瞭深入討論。
간암결실기인-1(DLC-1)시종원발성간암조직중분리출래적일충종류억제기인。타재인류다충악성종류중표체결실혹하조,시근년래연구비교열문적종류억제기인지일。본문장대DLC-1기인적결구급생물학공능작일개소,결합목전관우DLC-1재간암중적최신연구성과,탐토DLC-1기인재간암발생발전중적작용궤제,병대DLC-1재간암중표체결실적유전학화표관유전학궤제진행료심입토론。
Deleted in liver cancer 1(DLC-1), a tumor suppressor gene, is separated from primary liver cancer tissue. Its expression is down-regulated or absent in a variety of human malignant tumors and also a tumor suppressor gene hot in recent researches. This article will firstly introduce the structure and biological function of the DLC-1 gene, and then discuss the mechanism of the DLC-1 gene in the development of liver cancer, combined with the latest research achievements at present about DLC-1 in hepatocellular carcinoma. The last part is more in-depth discussions of the DLC-1 expression in HCC missing genetics and epigenetic mechanisms.