CAJ | 학술논문

目的：研究短疗程大剂量环磷酰胺和依托泊苷、体内去T细胞预处理方案自体移植治疗系统性红斑狼疮的疗效及安全性。方法：入组患者采髓后体外低温保存，预处理方案：环磷酰胺60 mg/kg，依托泊苷10~20 mg/kg，均于移植前的第1、2天应用；骨髓输注后第2~6天应用抗胸腺细胞球蛋白（ATG）3~5 mg/（kg·d）。结果：所有患者均成功实现了造血重建；患者白细胞重建时间8~14 d，中位时间11 d；血小板重建时间12~36 d，中位时间18 d；移植后原有肝肾功能损害逐渐改善，未发生移植相关死亡；移植前后狼疮活动指数、血沉、补体、抗核抗体比较差异有统计学意义（P<0.05）。结论：应用该方案进行自体移植，安全性好，疗效肯定，适合基层医院开展。
목적：연구단료정대제량배린선알화의탁박감、체내거T세포예처리방안자체이식치료계통성홍반랑창적료효급안전성。방법：입조환자채수후체외저온보존，예처리방안：배린선알60 mg/kg，의탁박감10~20 mg/kg，균우이식전적제1、2천응용；골수수주후제2~6천응용항흉선세포구단백（ATG）3~5 mg/（kg·d）。결과：소유환자균성공실현료조혈중건；환자백세포중건시간8~14 d，중위시간11 d；혈소판중건시간12~36 d，중위시간18 d；이식후원유간신공능손해축점개선，미발생이식상관사망；이식전후랑창활동지수、혈침、보체、항핵항체비교차이유통계학의의（P<0.05）。결론：응용해방안진행자체이식，안전성호，료효긍정，괄합기층의원개전。
Objective:To study the efficacy and safety of pretreatment regimen of high doses CTX and VP-16 combined with vivo T cell removal in autologous transplantation of Systemic Lupus Erythematosus(SLE). Method:After autologous bone marrow collection,the pretreatment regimen was given. The regimen included cyclophosphamide 60 mg/kg, etoposide 10-20 mg/kg,on the first day and the second day before the transplantation,antithymocyte globulin(ATG) 3-5 mg/(kg·d),from the second day to the sixth day after bone marrow infusion. Result:All patients successfully achieved hematopoietic reconstruction,the median time of white cells recovered was 11(8-14 )d,the median time of platelets recovered is 18(12-36)d,no transplant-related death occur;when the lupus activity index,ESR, complement and antinuclear antibodies were compared before and after transplantation,the difference were statistically significant(P<0.05). Conclusion:The application of this regimen have good safety,significant treatment effects,is suitable for primary hospitals.