世界最新医学信息文摘（电子版）
世界最新醫學信息文摘（電子版）
세계최신의학신식문적（전자판）
World Latest Medicine Information
2013年
11期
72-73
,共2页
血清总胆汁酸(TBA)水平%肝硬化%肝癌%梗阻性黄疸
血清總膽汁痠(TBA)水平%肝硬化%肝癌%梗阻性黃疸
혈청총담즙산(TBA)수평%간경화%간암%경조성황달
Serum total bile acid (associates) level%Liver cirrhosis%Cancer of the liver%Obstructive jaundice
目的探讨血清总胆汁酸水平在肝硬化、肝癌和梗阻性黄疸中的临床价值。方法选240例肝胆病患者作为病例组；选160例健康体检者作为对照组。两组TBA检测均采用酶循环法。并同时检测GGT、ALP、AST、ALT的活性指标。分析检测结果并比较。结果病例组与对照组的血清TBA水平比较，P ＜0.01，前者明显高于后者；肝硬化组（阳性率100%）、梗阻性黄疸组（阳性率100%）与肝癌组（阳性率80%）的血清TBA水平比较，P＜0.01，前者明显高于后者；病例组的血清TBA水平的阳性率与传统肝功能酶学指标（GGT、ALP、AST、ALT）比较，前者高于后者，P <0.01。结论 TBA作为肝细胞损伤和胆道梗阻的检测指标，具有较高的灵敏度和特异性，优于常规的检测指标，是一种良好的检测指标。TBA水平为肝胆疾病的早期诊断提供了有利依据，给病情检测带来了重要的临床价值。同时应联合检测其他肝功能指标以提高肝胆疾病的检测率。
目的探討血清總膽汁痠水平在肝硬化、肝癌和梗阻性黃疸中的臨床價值。方法選240例肝膽病患者作為病例組；選160例健康體檢者作為對照組。兩組TBA檢測均採用酶循環法。併同時檢測GGT、ALP、AST、ALT的活性指標。分析檢測結果併比較。結果病例組與對照組的血清TBA水平比較，P ＜0.01，前者明顯高于後者；肝硬化組（暘性率100%）、梗阻性黃疸組（暘性率100%）與肝癌組（暘性率80%）的血清TBA水平比較，P＜0.01，前者明顯高于後者；病例組的血清TBA水平的暘性率與傳統肝功能酶學指標（GGT、ALP、AST、ALT）比較，前者高于後者，P <0.01。結論 TBA作為肝細胞損傷和膽道梗阻的檢測指標，具有較高的靈敏度和特異性，優于常規的檢測指標，是一種良好的檢測指標。TBA水平為肝膽疾病的早期診斷提供瞭有利依據，給病情檢測帶來瞭重要的臨床價值。同時應聯閤檢測其他肝功能指標以提高肝膽疾病的檢測率。
목적탐토혈청총담즙산수평재간경화、간암화경조성황달중적림상개치。방법선240례간담병환자작위병례조；선160례건강체검자작위대조조。량조TBA검측균채용매순배법。병동시검측GGT、ALP、AST、ALT적활성지표。분석검측결과병비교。결과병례조여대조조적혈청TBA수평비교，P ＜0.01，전자명현고우후자；간경화조（양성솔100%）、경조성황달조（양성솔100%）여간암조（양성솔80%）적혈청TBA수평비교，P＜0.01，전자명현고우후자；병례조적혈청TBA수평적양성솔여전통간공능매학지표（GGT、ALP、AST、ALT）비교，전자고우후자，P <0.01。결론 TBA작위간세포손상화담도경조적검측지표，구유교고적령민도화특이성，우우상규적검측지표，시일충량호적검측지표。TBA수평위간담질병적조기진단제공료유리의거，급병정검측대래료중요적림상개치。동시응연합검측기타간공능지표이제고간담질병적검측솔。
Objective To investigate the serum total bile acid level in liver cirrhosis, liver cancer and the clinical value of obstructive jaundice. Methods Selected 240 cases of liver disease as case group;Selected 160 healthy physical examination as a control. Two groups of associates detection method of enzyme in each cycle. Detection of GGT and ALP, AST, ALT activity index. Analysis and compare the test results. Results Case group compared with control group of serum levels of associates, P<0.01, the former is significantly higher than the latter;Cirrhosis of the liver (positive rate 100%), obstructive jaundice group (positive rate 100%) and liver cancer group (positive rate 80%), serum levels of associates P <0.01, the former is significantly higher than the latter;Cases of the positive rate of serum levels of associates with traditional index of liver enzyme (GGT and ALP, AST and ALT) comparison, the former is higher than the latter, P <0.01. Conclusions Associates as indicators of Liver cells injury and detection of biliary obstruction, have higher sensitivity and specificity and is superior to the conventional detection indexes, is a kind of good detection index. Associates level provides a good basis for the early diagnosis of liver disease, bring disease detection has important clinical value. At the same time, other liver function indicators should be united detection in order to improve the detection rate of liver and gallbladder disease.
