CAJ | 학술논문

本文探讨禽流感病毒遗传进化过程中基因突变与致病力的关系。禽流感病毒是分节段的负链RNA病毒，有11种蛋白，由8个基因片段组成。由于RNA聚合酶缺乏矫正功能，出错率较高，所以RNA病毒的突变率比DNA病毒高。禽流感病毒是一个通过大量遗传变异而快速适应环境的病原微生物，其致病性是多种因素协同作用的结果。
본문탐토금류감병독유전진화과정중기인돌변여치병력적관계。금류감병독시분절단적부련RNA병독，유11충단백，유8개기인편단조성。유우RNA취합매결핍교정공능，출착솔교고，소이RNA병독적돌변솔비DNA병독고。금류감병독시일개통과대량유전변이이쾌속괄응배경적병원미생물，기치병성시다충인소협동작용적결과。
Objective To investigate the relation between the gene mutation and virulence in the avian influenza virus genetic evolution. Avian influenza virus proteins have 11 segmented negative-strand RNA virus, which consists of eight gene fragments. RNA virus DNA virus mutation rates than high, resulting in a higher error rate, because RNA polymerase lacking correction. Avian influenza virus is a genetic variation through a large and rapid adaptation to the environment of the pathogenic microorganisms, which are pathogenic factors synergistic results.This study genetic variation of avian influenza virus (AIV) from multiple strains isolates.