世界最新医学信息文摘（电子版）
世界最新醫學信息文摘（電子版）
세계최신의학신식문적（전자판）
World Latest Medicine Information
2013年
11期
8-9
,共2页
糖尿病肾病%阿魏酸钠%超敏C反应蛋白%肾功能
糖尿病腎病%阿魏痠鈉%超敏C反應蛋白%腎功能
당뇨병신병%아위산납%초민C반응단백%신공능
Diabetic nephropathy%Ferulate%Ultra-sensitivity C-reactive protein%Renal function
目的观察阿魏酸钠对糖尿病肾病(DN)患者血清超敏C反应蛋白(hs-CRP)和肾功能的影响。方法92例DN患者随机分为对照组和治疗组各46例，观察两组治疗前、治疗2周和4周后血肌酐(CRE)、尿素氮(BUN)和hs-CRP浓度。结果两组治疗前后CRE、BUN和hs-CRP比较，两组治疗后两周均高度显著低于治疗前，P <0.01；治疗后四周又高度显著低于治疗后两周，P <0.01；治疗组更优于对照组P <0.01；由于肾功能明显受损，CRE、BUN与hs-CRP均显著高于正常值数倍，P ＜0.01；hs-CRP与CRE和BUN呈同向变化，作直线相关分析均呈高度显著正相关P ＜0.01。结论阿魏酸钠可能通过抑制DN患者血清中炎症反应，改善肾功能，疗效显著。
目的觀察阿魏痠鈉對糖尿病腎病(DN)患者血清超敏C反應蛋白(hs-CRP)和腎功能的影響。方法92例DN患者隨機分為對照組和治療組各46例，觀察兩組治療前、治療2週和4週後血肌酐(CRE)、尿素氮(BUN)和hs-CRP濃度。結果兩組治療前後CRE、BUN和hs-CRP比較，兩組治療後兩週均高度顯著低于治療前，P <0.01；治療後四週又高度顯著低于治療後兩週，P <0.01；治療組更優于對照組P <0.01；由于腎功能明顯受損，CRE、BUN與hs-CRP均顯著高于正常值數倍，P ＜0.01；hs-CRP與CRE和BUN呈同嚮變化，作直線相關分析均呈高度顯著正相關P ＜0.01。結論阿魏痠鈉可能通過抑製DN患者血清中炎癥反應，改善腎功能，療效顯著。
목적관찰아위산납대당뇨병신병(DN)환자혈청초민C반응단백(hs-CRP)화신공능적영향。방법92례DN환자수궤분위대조조화치료조각46례，관찰량조치료전、치료2주화4주후혈기항(CRE)、뇨소담(BUN)화hs-CRP농도。결과량조치료전후CRE、BUN화hs-CRP비교，량조치료후량주균고도현저저우치료전，P <0.01；치료후사주우고도현저저우치료후량주，P <0.01；치료조경우우대조조P <0.01；유우신공능명현수손，CRE、BUN여hs-CRP균현저고우정상치수배，P ＜0.01；hs-CRP여CRE화BUN정동향변화，작직선상관분석균정고도현저정상관P ＜0.01。결론아위산납가능통과억제DN환자혈청중염증반응，개선신공능，료효현저。
Objective To observe Chae Wei sodium diabetic nephropathy (DN) in patients with serum high sensitivity C-reactive protein (hs-CRP) and renal function. Methods 92 cases of DN were randomly divided into control group and the treatment group, 46 cases were observed before treatment, 2 weeks and 4 weeks after the serum creatinine (CRE), blood urea nitrogen (BUN) and hs-CRP levels. Results The results before and after treatment CRE, BUN and hs-CRP compared to two weeks after treatment in both groups were highly significantly lower than before treatment, P <0.01;another four weeks after treatment was significantly lower height weeks after treatment, P <0.01;treatment group more than the control group, P <0.01;due to renal function was significantly impaired, CRE, BUN and hs-CRP were significantly higher than normal times, P <0.01;hs-CRP with CRE and BUN were same direction for linear correlation analysis showed a highly significant positive correlationP<0.01. Conclusion SF may inhibit the inflammatory response in DN patients, improve renal function, a significant effect.
