CAJ | 학술논문

目的比较缬沙坦与贝那普利治疗轻中度原发性高血压的疗效及其不良反应。方法98例轻中度原发高血压患者，随机分为两组，缬沙坦组50例，口服缬沙坦80~160mg/d，贝那普利组48例，口服贝那普利10~20mg/d，6周为1个疗程。观察用药前后血压、心率、心电图、生化等指标的变化。结果缬沙坦组有效率为74.3%；贝那普利组有效率为76.5%，两组均有明显降压作用，两组比较差异无统计学意义（P＞0.05），两组治疗前后的心电图、心率、生化等均无明显变化。不良反应缬沙坦组无干咳发生，贝那普利组干咳发生率为10.4%。结论缬沙坦与贝那普利治疗轻中度原发高血压疗效相似，均为安全、有效，副作用少的长效降压药，缬沙坦耐受性较好。
목적비교힐사탄여패나보리치료경중도원발성고혈압적료효급기불량반응。방법98례경중도원발고혈압환자，수궤분위량조，힐사탄조50례，구복힐사탄80~160mg/d，패나보리조48례，구복패나보리10~20mg/d，6주위1개료정。관찰용약전후혈압、심솔、심전도、생화등지표적변화。결과힐사탄조유효솔위74.3%；패나보리조유효솔위76.5%，량조균유명현강압작용，량조비교차이무통계학의의（P＞0.05），량조치료전후적심전도、심솔、생화등균무명현변화。불량반응힐사탄조무간해발생，패나보리조간해발생솔위10.4%。결론힐사탄여패나보리치료경중도원발고혈압료효상사，균위안전、유효，부작용소적장효강압약，힐사탄내수성교호。
Objective To compare the clinical effect and side-effects of valsartan and benazepril in the treatment of mild and moderate primary hypertension. Methods 98 patients with mild and moderate primary hypertension were randomly divided into two groups. 50 cases of valsartan group were treated with oral valsartan in 80-160mg/day, while 48 cases of benazepril group were treated with oral benazepril in 10-20mg/day, a course of treatment was six weeks. The change of blood pressure, heart rate, electrocardiogram, biochemical indicators before and after using drug were observed. Results The effective rate of valsartan group was 74.3%, the effective rate of benazepril group was 76.5%, and two groups had significant antihypertensive effect, the difference was not significant(P>0.05),and the electrocardiogram, heart rate and biochemical of two groups before and after the treatment had no obvious change. In adverse reactions, valsartan group had no dry cough, the incidence of dry cough of benazepril group was 10.4%. Conclusion Valsartan and benazepril in the treatment of mild and moderate primary hypertension had similar curative effect,and are safe, effective, less side effects long-acting antihypertensives, but the tolerance of valsartan is better.