CAJ | 학술논문

目的探讨10日序贯疗法与四联疗法治疗幽门螺杆菌感染疗效对比。方法随机选择对照组42例，采用四联疗法进行治疗：阿莫西林1000mg+克拉霉素500mg+奥美拉唑20mg+枸橼酸铋钾220mg，Bid，治疗10d；治疗组43例，应用10日序贯疗法治疗：前5d给予阿莫西林1000mg+奥美拉唑20mg，Bid；后5d给予甲硝唑400mg+克拉霉素500mg+奥美拉唑20mg，Bid。结果两组经10d治疗后，停PPI及抗生素满4周，经13C-UBT试验阴性者为幽门螺杆菌（H.pylori）根治成功。实验结果显示：对照组根治成功33例，根除率达78.6%（33/42）；治疗组根治成功40例，根除率达93.0%（40/43）。应用统计学分析，两组比较差异具有统计学意义（P＜0.05）。结论本实验结果显示，两组治疗方法对治疗幽门螺杆菌感染均有效，同比治疗组疗效更佳，具有重要的临床意义。
목적탐토10일서관요법여사련요법치료유문라간균감염료효대비。방법수궤선택대조조42례，채용사련요법진행치료：아막서림1000mg+극랍매소500mg+오미랍서20mg+구연산필갑220mg，Bid，치료10d；치료조43례，응용10일서관요법치료：전5d급여아막서림1000mg+오미랍서20mg，Bid；후5d급여갑초서400mg+극랍매소500mg+오미랍서20mg，Bid。결과량조경10d치료후，정PPI급항생소만4주，경13C-UBT시험음성자위유문라간균（H.pylori）근치성공。실험결과현시：대조조근치성공33례，근제솔체78.6%（33/42）；치료조근치성공40례，근제솔체93.0%（40/43）。응용통계학분석，량조비교차이구유통계학의의（P＜0.05）。결론본실험결과현시，량조치료방법대치료유문라간균감염균유효，동비치료조료효경가，구유중요적림상의의。
Objective To investigate the curative effect comparison of 10 days sequential therapy and quadruple therapy in treatment of helicobacter pylori infection. Methods 42 cases of helicobacter pylori infection were randomly selected as control group,and were given quadruple therapy:1000mg amoxicillin + 500mg clarithromycin+ 20mg omeprazole + 220mg bismuth potassium citrate, Bid, for 10 days; 43 cases of helicobacter pylori infection were randomly selected as treatment group, and were given 10 days sequential therapy:1000mg amoxicillin+20mg omeprazole for the first 5 days,Bid,and 400mg metronidazole+500mg clarithromycin+omeprazole 20 mg for the next 5 days,Bid. Results After treatment for 10 days, stop PPI and antibiotics for 4 weeks, negative 13C-UBT test means helicobacter pylori (H.p ylori) was cured successfully. Experiment results showed that 33 cases of the control group were cured successfully, eradication rate was 78.6%(33/42);40 cases of the treatment group were cured successfully, eradication rate was 93.0% (40/43). Differences of two groups was statistically significant by statistical analysis (P < 0.05). Conclusion The experiment results show that treatment methods of two groups in treatment of helicobacter pylori infection both are effective, curative effect is better of the treatment group,which has the vital clinical significance.