CAJ | 학술논문

目的探讨柴芩泻心汤加减治疗肝胃不和型慢性浅表性胃炎的临床治疗效果。方法选择我市所属医院2010年6月～2011年7月收治的肝胃不和型慢性浅表性胃炎患者120例进行回顾性分析，根据治疗方法分为观察组与对照组，各60例，观察组患者给予口服柴芩泻心汤加减，1剂/日，水煎服；对照组患者给予口服多潘立酮片，10mg/次，3次/d，饭前温水送服。以8个周为1个疗程，观察记录并比较治疗前后两组患者的临床症状以及胃镜检查的变化情况，评估柴芩泻心汤加减治疗肝胃不和型慢性浅表性胃炎的临床疗效及安全性。结果两组患者经治疗后各项临床症状较治疗前均明显改善，且观察组明显优于对照组（t=7.12，7.05和7.03，均P＜0.05）；胃镜检查各项指标明显好转，且观察组明显好于对照组（t=7.12，7.05和7.03，均P＜0.05）；观察组的总有效率为93.3％，明显高于对照组的73.3％（x2=9.572，P＜0.05）。治疗过程中均无明显不良反应发生。结论柴芩泻心汤加减治疗肝胃不和型慢性浅表性胃炎临床疗效显著，安全性高，值得临床推广应用。
목적탐토시금사심탕가감치료간위불화형만성천표성위염적림상치료효과。방법선택아시소속의원2010년6월～2011년7월수치적간위불화형만성천표성위염환자120례진행회고성분석，근거치료방법분위관찰조여대조조，각60례，관찰조환자급여구복시금사심탕가감，1제/일，수전복；대조조환자급여구복다반립동편，10mg/차，3차/d，반전온수송복。이8개주위1개료정，관찰기록병비교치료전후량조환자적림상증상이급위경검사적변화정황，평고시금사심탕가감치료간위불화형만성천표성위염적림상료효급안전성。결과량조환자경치료후각항림상증상교치료전균명현개선，차관찰조명현우우대조조（t=7.12，7.05화7.03，균P＜0.05）；위경검사각항지표명현호전，차관찰조명현호우대조조（t=7.12，7.05화7.03，균P＜0.05）；관찰조적총유효솔위93.3％，명현고우대조조적73.3％（x2=9.572，P＜0.05）。치료과정중균무명현불량반응발생。결론시금사심탕가감치료간위불화형만성천표성위염림상료효현저，안전성고，치득림상추엄응용。
Objective To investigate the clinical efficacy of Chaiqin xiexin decoction addition and subtraction in the treatment of liver-stomach disharmony chronic superficial gastritis. Methods 120 patients with liver-stomach disharmony chronic superficial gastritis admitted to the municipal hospitals from June 2010 to July 2011 were analyzed retrospectively and divided into the observation group and the control group according to the treatment method, with 60 patients in each group. The observation group was given oral administration of Chaiqin Xiexin decoction addition and subtraction 1 prescription/day; The control group was given oral administration of domperidone tablets 10 mg/day before meals with warm water. With 8 weeks as 1 treatment course, the changes of clinical symptoms and gastroscopic examination of the two groups before and after the treatment were observed and recorded. The clinical efficacy and safety of Chaiqin Xiexin decoction addition and subtraction treatment of liver-stomach disharmony chronic superficial gastritis were evaluated. Results After the treatment, each clinical symptom of both groups significantly improved compared to those before the treatment, with the observation group superior to the control group (t=7.12, 7.05 and 7.03, P<0.05 for all); Each indicator of gastroscopic examination significantly improved, with the observation group superior to the control group (t=7.12, 7.05 and 7.03, P < 0.05 for all). The observation group had a total response rate of 93.3%, which was significantly higher than the 73.3% of the control group (x2=9.572, P < 0.05). During the treatment process, no obvious adverse reactions occurred. Conclusion In the treatment of liver-stomach disharmony chronic superficial gastritis, Chaiqin Xiexin decoction addition and subtraction shows significant clinical efficacy and is highly safe, thereby worthy of clinical promotion and application.