目的探讨排除再生障碍性贫血及白血病，MM等能确诊血小板生成减少外一些疾病巨核细胞多形性改变的意义。将巨核细胞多形性形态定义5类[1]分别为：Ⅰ型（包含型），Ⅱ型（少分叶核型）Ⅲ型（巨大多分叶核型），Ⅳ型（小核固缩型），Ⅴ型（脱落型），另外我们把正常巨核细胞分为Ⅵ型。方法136例血小板减少性患者采取骨髓0.1~0.3ml，获取骨髓涂片标本，骨髓涂片用瑞氏染色法染色，将骨髓片中的巨核细胞进一步分析。结果①脑梗塞及高血压5例：Ⅱ5.5%,Ⅲ5.5%,Ⅴ5.5%,Ⅵ83.5%.②不明原因巨核细胞成熟障碍30例，I 0.2%,Ⅱ4.1%,Ⅲ4.7%,Ⅳ0.4%,Ⅴ8.2%,Ⅵ型82.4%。③巨核细胞减少4例，Ⅱ5.5%,Ⅲ11%,Ⅴ1.5%，Ⅵ72%。④增生性贫血24例，Ⅰ0.33%,Ⅱ,2.65%,Ⅲ,0.99%,Ⅳ0.33%,Ⅴ,5.96%,Ⅵ,89.74%。⑤ITP20例：Ⅰ0.2%,Ⅱ2%,Ⅲ1%,Ⅳ0.8%,Ⅴ4%,Ⅵ92%。⑥MDS8例：Ⅱ0.8%,Ⅲ11.9%,Ⅴ9.5%,Ⅵ86.3%,小原巨核细胞9.5%。⑦巨幼细胞性贫血4例：Ⅲ型20%，Ⅴ型3.9%,Ⅵ型76.1%。⑧粒细胞减少症3例：Ⅴ型7%，Ⅵ型93%。⑨人粒细胞无形体病立克次病1例：Ⅲ型4个，Ⅴ型2个，Ⅵ型28个。结论①以上9类中Ⅰ型Ⅱ型Ⅳ型巨核细胞较低。②MDS中Ⅲ型Ⅴ型巨核细胞显著增高。 MDS小原巨核细胞比例增高。③巨幼细胞性贫血Ⅲ型巨核细胞比例增高。④脑梗塞及高血压病Ⅱ型Ⅲ型巨核细胞比例增高。
目的探討排除再生障礙性貧血及白血病，MM等能確診血小闆生成減少外一些疾病巨覈細胞多形性改變的意義。將巨覈細胞多形性形態定義5類[1]分彆為：Ⅰ型（包含型），Ⅱ型（少分葉覈型）Ⅲ型（巨大多分葉覈型），Ⅳ型（小覈固縮型），Ⅴ型（脫落型），另外我們把正常巨覈細胞分為Ⅵ型。方法136例血小闆減少性患者採取骨髓0.1~0.3ml，穫取骨髓塗片標本，骨髓塗片用瑞氏染色法染色，將骨髓片中的巨覈細胞進一步分析。結果①腦梗塞及高血壓5例：Ⅱ5.5%,Ⅲ5.5%,Ⅴ5.5%,Ⅵ83.5%.②不明原因巨覈細胞成熟障礙30例，I 0.2%,Ⅱ4.1%,Ⅲ4.7%,Ⅳ0.4%,Ⅴ8.2%,Ⅵ型82.4%。③巨覈細胞減少4例，Ⅱ5.5%,Ⅲ11%,Ⅴ1.5%，Ⅵ72%。④增生性貧血24例，Ⅰ0.33%,Ⅱ,2.65%,Ⅲ,0.99%,Ⅳ0.33%,Ⅴ,5.96%,Ⅵ,89.74%。⑤ITP20例：Ⅰ0.2%,Ⅱ2%,Ⅲ1%,Ⅳ0.8%,Ⅴ4%,Ⅵ92%。⑥MDS8例：Ⅱ0.8%,Ⅲ11.9%,Ⅴ9.5%,Ⅵ86.3%,小原巨覈細胞9.5%。⑦巨幼細胞性貧血4例：Ⅲ型20%，Ⅴ型3.9%,Ⅵ型76.1%。⑧粒細胞減少癥3例：Ⅴ型7%，Ⅵ型93%。⑨人粒細胞無形體病立剋次病1例：Ⅲ型4箇，Ⅴ型2箇，Ⅵ型28箇。結論①以上9類中Ⅰ型Ⅱ型Ⅳ型巨覈細胞較低。②MDS中Ⅲ型Ⅴ型巨覈細胞顯著增高。 MDS小原巨覈細胞比例增高。③巨幼細胞性貧血Ⅲ型巨覈細胞比例增高。④腦梗塞及高血壓病Ⅱ型Ⅲ型巨覈細胞比例增高。
목적탐토배제재생장애성빈혈급백혈병，MM등능학진혈소판생성감소외일사질병거핵세포다형성개변적의의。장거핵세포다형성형태정의5류[1]분별위：Ⅰ형（포함형），Ⅱ형（소분협핵형）Ⅲ형（거대다분협핵형），Ⅳ형（소핵고축형），Ⅴ형（탈락형），령외아문파정상거핵세포분위Ⅵ형。방법136례혈소판감소성환자채취골수0.1~0.3ml，획취골수도편표본，골수도편용서씨염색법염색，장골수편중적거핵세포진일보분석。결과①뇌경새급고혈압5례：Ⅱ5.5%,Ⅲ5.5%,Ⅴ5.5%,Ⅵ83.5%.②불명원인거핵세포성숙장애30례，I 0.2%,Ⅱ4.1%,Ⅲ4.7%,Ⅳ0.4%,Ⅴ8.2%,Ⅵ형82.4%。③거핵세포감소4례，Ⅱ5.5%,Ⅲ11%,Ⅴ1.5%，Ⅵ72%。④증생성빈혈24례，Ⅰ0.33%,Ⅱ,2.65%,Ⅲ,0.99%,Ⅳ0.33%,Ⅴ,5.96%,Ⅵ,89.74%。⑤ITP20례：Ⅰ0.2%,Ⅱ2%,Ⅲ1%,Ⅳ0.8%,Ⅴ4%,Ⅵ92%。⑥MDS8례：Ⅱ0.8%,Ⅲ11.9%,Ⅴ9.5%,Ⅵ86.3%,소원거핵세포9.5%。⑦거유세포성빈혈4례：Ⅲ형20%，Ⅴ형3.9%,Ⅵ형76.1%。⑧립세포감소증3례：Ⅴ형7%，Ⅵ형93%。⑨인립세포무형체병립극차병1례：Ⅲ형4개，Ⅴ형2개，Ⅵ형28개。결론①이상9류중Ⅰ형Ⅱ형Ⅳ형거핵세포교저。②MDS중Ⅲ형Ⅴ형거핵세포현저증고。 MDS소원거핵세포비례증고。③거유세포성빈혈Ⅲ형거핵세포비례증고。④뇌경새급고혈압병Ⅱ형Ⅲ형거핵세포비례증고。
Objective To investigate excluding aplastic anemia and leukemia, MM can diagnose some diseases decreased platelet and megakaryocyte polymorphic change significance. The megakaryocyte polymorphic form defined 5 types of [1] were:type I (including type),type Ⅱ(smal leaf type III (karyotype) huge multilobular karyotype), typeⅣ(smal nuclear pyknosis type),V(drop type),we put the normal megakaryocyte divided into type VI. Methods:136 cases of thrombocytopenic patients to take 0.1-0.3 ml of bone marrow,bone marrow smear specimens were obtained,bone marrow smears stained with Wright's staining staining,the megakaryocyte bone marrow in the further analysis. Results:5 cases of cerebral infarction and hypertension:II 5.5%, Ⅲ5.5%, V 5.5%, 30 cases of 83.5%, the unexplained megakaryocyte maturation disorder of I 0.2%, 4.1%,4.7% and 0.4% V Ⅲ, Ⅳ,8.2%,and 82.4% of type VI.The megakaryocyte reduced in 4 cases,5.5%,III 11%, V 1.5%, V 72%. ④ proliferative anemia in 24 cases,I 0.33%,II,III,IV,2.65%,0.99%,0.33%,5.96%,V,VI,89.74%.The ITP20 example:I 0.2%, II 2%,III 1%,IV 0.8%,V 4%,V 92%.MDS8:0.8%casesⅡ,Ⅲ11.9%,9.5%V, VI 86.3%, 9.5%smal megakaryocyte.In 4 cases the megaloblastic anemia:type 20%,3.9%type Ⅴ, Ⅵ type 76.1%. ⑧neutropenia in 3 cases:7% typeⅤ, Ⅵ type 93%.1 cases of zoonotic disease made the human granulocytic anaplasmosis:type4,2typeⅤ, Ⅵ type 28. Conclusion: the above 9 categories of 1 type I and II type IV megakaryocyte low.Type III2:MDS Ⅴ megakaryocyte increased significantly.Increased MDS smal megakaryoblastic ratio.3:the increase of megakaryocyte proportion of megaloblastic anemia type III.4:the increase of megakaryocyte percentage of cerebral infarction and hypertensive disease type III.
