医学信息
醫學信息
의학신식
MEDICAL INFORMATION
2013年
16期
325-326
,共2页
岳永猛%赵俊锦%王高%谭兴中%熊陈%陈力
嶽永猛%趙俊錦%王高%譚興中%熊陳%陳力
악영맹%조준금%왕고%담흥중%웅진%진력
帕瑞昔布钠%吗啡%镇痛%骨科手术%非甾体抗炎药
帕瑞昔佈鈉%嗎啡%鎮痛%骨科手術%非甾體抗炎藥
파서석포납%마배%진통%골과수술%비치체항염약
Parecoxib sodium%morPhine%analgesic%OrthoPedic surgery%Non-steroidal anti-inflammatory drugs
目的探讨帕瑞昔布钠对硬膜外腔阻滞下骨科手术术后自控静脉镇痛吗啡用量的影响。方法2010年2月~2013年2月收入的90例择期硬膜外腔阻滞下骨科手术患者，随机分为对照组和实验组。对照组单纯采用吗啡患者自控镇痛，实验组采用帕瑞昔布钠和吗啡患者自控镇痛。结果实验组在给药后4h、6h、12h和24h后VAS评分低于对照组，差异有统计学意义（P<0.05）。对照组给药后12h吗啡用量(7.4±0.9)mg，给药后24h吗啡用量10.6±1.4mg。实验组给药后12h吗啡用量(5.4±0.7)mg，给药后24h吗啡用量(7.1±1.1)mg。实验组给药后12h和24h吗啡用量低于对照组，差异有统计学意义（P<0.05）。实验组给药后12h和24hPCA总次数和PCA有效次数均低于对照组，差异有统计学意义（P<0.05）。两组患者术前和给药后肝肾功能指标和不良反应发生率无统计学意义（P＞0.05）。结论在骨科患者手术后静脉给予帕瑞昔布钠可以减轻骨科患者术后的疼痛，减少吗啡用量，而且安全可靠。
目的探討帕瑞昔佈鈉對硬膜外腔阻滯下骨科手術術後自控靜脈鎮痛嗎啡用量的影響。方法2010年2月~2013年2月收入的90例擇期硬膜外腔阻滯下骨科手術患者，隨機分為對照組和實驗組。對照組單純採用嗎啡患者自控鎮痛，實驗組採用帕瑞昔佈鈉和嗎啡患者自控鎮痛。結果實驗組在給藥後4h、6h、12h和24h後VAS評分低于對照組，差異有統計學意義（P<0.05）。對照組給藥後12h嗎啡用量(7.4±0.9)mg，給藥後24h嗎啡用量10.6±1.4mg。實驗組給藥後12h嗎啡用量(5.4±0.7)mg，給藥後24h嗎啡用量(7.1±1.1)mg。實驗組給藥後12h和24h嗎啡用量低于對照組，差異有統計學意義（P<0.05）。實驗組給藥後12h和24hPCA總次數和PCA有效次數均低于對照組，差異有統計學意義（P<0.05）。兩組患者術前和給藥後肝腎功能指標和不良反應髮生率無統計學意義（P＞0.05）。結論在骨科患者手術後靜脈給予帕瑞昔佈鈉可以減輕骨科患者術後的疼痛，減少嗎啡用量，而且安全可靠。
목적탐토파서석포납대경막외강조체하골과수술술후자공정맥진통마배용량적영향。방법2010년2월~2013년2월수입적90례택기경막외강조체하골과수술환자，수궤분위대조조화실험조。대조조단순채용마배환자자공진통，실험조채용파서석포납화마배환자자공진통。결과실험조재급약후4h、6h、12h화24h후VAS평분저우대조조，차이유통계학의의（P<0.05）。대조조급약후12h마배용량(7.4±0.9)mg，급약후24h마배용량10.6±1.4mg。실험조급약후12h마배용량(5.4±0.7)mg，급약후24h마배용량(7.1±1.1)mg。실험조급약후12h화24h마배용량저우대조조，차이유통계학의의（P<0.05）。실험조급약후12h화24hPCA총차수화PCA유효차수균저우대조조，차이유통계학의의（P<0.05）。량조환자술전화급약후간신공능지표화불량반응발생솔무통계학의의（P＞0.05）。결론재골과환자수술후정맥급여파서석포납가이감경골과환자술후적동통，감소마배용량，이차안전가고。
Objective To investigate influence of Parecoxib sodium for PostoPerative analgesia on morPhine consumPtion of orthoPedic Patient-control ed ePidural analgesia. Methods During February 2010 to February 2013,90 cases were randomly selected and divided into two grouPs. Control group included 45 cases only used morPhine for Patient-control ed analgesia and test group included 60 cases used arecoxib sodium and morPhine for Patient-control ed analgesia. Results The VAS scores of test group after administration of 4h,6h,12h and 24h were significantly lower than control group(P<0.05). MorPhine consumPtion of the control grouP after administration of 12h and 24h were 7.4 ±0.9mg and 10.6 ±1.4mg.MorPhine consumPtion of test grouP after administration of 12h and 24h were 5.4 ±0.7mg and 7.1 ±1.1mg.MorPhine consumPtion of test group after administration of 12h and 24h were significantly lower than control group (P<0.05). Total number of PCA times and ef ective number of PCA times of test group after administration of 12h and 24h were significantly lower than control group (P<0.05). The liver and kidney function indicators and the incidence of adverse events between two groups before and after administration had no statistical y significant dif erence (P>0.05). Conclusions To use Parecoxib sodium for PostoPerative analgesia can reduce morPhine consumPtion of orthoPedic Patient-control ed ePidural analgesia.
