医学信息
醫學信息
의학신식
MEDICAL INFORMATION
2013年
16期
313-314
,共2页
袁霞%张易青%郭新建%王涛%李占全%崔森%柴克霞%冀林华
袁霞%張易青%郭新建%王濤%李佔全%崔森%柴剋霞%冀林華
원하%장역청%곽신건%왕도%리점전%최삼%시극하%기림화
慢性高原病%缺氧诱导因子-1α%碱性成纤维生长因子%凋亡抑制蛋白%微血管密度
慢性高原病%缺氧誘導因子-1α%堿性成纖維生長因子%凋亡抑製蛋白%微血管密度
만성고원병%결양유도인자-1α%감성성섬유생장인자%조망억제단백%미혈관밀도
Chronic mountain sickness%Hypoxia-inducible factor-1α%Survivin%Basic fibroblast growth factor%Microvessel density
目的探讨HIF-1α、bFGF、Survivin在慢性高原病（CMS）发展过程中的意义及其对血管生成的影响。方法应用免疫组织化学 SP法检测 HIF-1α、bFGF及Survivin在30例CMS患者（CMS组）及20例长期居住西宁地区健康人（对照组）骨髓组织中的表达，并计数CD34标记骨髓组织的微血管密度(MVD)结果 HIF-1α、bFGF及Survivin 在CMS组阳性表达率均显著高于对照组（P值均＜0.01）；MVD在CMS组也明显高于对照组（P＜0.01）。HIF-1α、bFGF、Survivin在CMS组的阳性表达率、MVD及Hb相互间均呈显著正相关（均为P＜0.01）。结论 HIF-1α、bFGF和Survivin 在CMS骨髓组织中表达升高， MVD增加，提示 Survivin可能通过抑制细胞凋亡，与HIF-1α及bFGF协同促进血管生成和红细胞增殖，参与CMS的发生发展。
目的探討HIF-1α、bFGF、Survivin在慢性高原病（CMS）髮展過程中的意義及其對血管生成的影響。方法應用免疫組織化學 SP法檢測 HIF-1α、bFGF及Survivin在30例CMS患者（CMS組）及20例長期居住西寧地區健康人（對照組）骨髓組織中的錶達，併計數CD34標記骨髓組織的微血管密度(MVD)結果 HIF-1α、bFGF及Survivin 在CMS組暘性錶達率均顯著高于對照組（P值均＜0.01）；MVD在CMS組也明顯高于對照組（P＜0.01）。HIF-1α、bFGF、Survivin在CMS組的暘性錶達率、MVD及Hb相互間均呈顯著正相關（均為P＜0.01）。結論 HIF-1α、bFGF和Survivin 在CMS骨髓組織中錶達升高， MVD增加，提示 Survivin可能通過抑製細胞凋亡，與HIF-1α及bFGF協同促進血管生成和紅細胞增殖，參與CMS的髮生髮展。
목적탐토HIF-1α、bFGF、Survivin재만성고원병（CMS）발전과정중적의의급기대혈관생성적영향。방법응용면역조직화학 SP법검측 HIF-1α、bFGF급Survivin재30례CMS환자（CMS조）급20례장기거주서저지구건강인（대조조）골수조직중적표체，병계수CD34표기골수조직적미혈관밀도(MVD)결과 HIF-1α、bFGF급Survivin 재CMS조양성표체솔균현저고우대조조（P치균＜0.01）；MVD재CMS조야명현고우대조조（P＜0.01）。HIF-1α、bFGF、Survivin재CMS조적양성표체솔、MVD급Hb상호간균정현저정상관（균위P＜0.01）。결론 HIF-1α、bFGF화Survivin 재CMS골수조직중표체승고， MVD증가，제시 Survivin가능통과억제세포조망，여HIF-1α급bFGF협동촉진혈관생성화홍세포증식，삼여CMS적발생발전。
Objective To Investigate the roles of HIF-1α and bFGF and Survivin in development of chronic mountain sickness (CMS) and their ef ects on angiogenesis. Methods The samples of bone marrow used in this study were obtained from 30 patients with CMS (CMS group)and 20 healthy adults (control group). The expressions of HIF-1α and bFGF and Survivin in bone marrows were detected using the SP immunohistochemistry technique and the MVD in bone marrow was measured by counting the vascular endothelial cel s labeled by anti-CD34 monoclonal antibody. The results were analyzed comparatively. Results The positive rates of HIF-1α and bFGF and Survivin in CMS group were significant higher than that in control group (P<0.01). MVD in CMS groupwas significantly higher than that in control group (P<0.01) .In the CMS group,there were positive correlations in the positive rates of HIF-1αand bFGF and Survivin, MVD and Hb each other (al P<0.01). Conclusions The results of this study showed that there were over expressions of HIF-1αand bFGF and Survivin, and the MVD increased in bone marrow of CMS. It was suggested that the HIF-1αand bFGF and Survivin may play a crucial role in generation and progression of CMS through contributing to the angiogenesis and the erythrocyte proliferation in CMS .
