CAJ | 학술논문

目的探讨泮托拉唑预防冠脉支架术后消化道出血的安全性及有效性。方法接受冠脉支架术的患者240例随机分为对照组(120例)及泮托拉唑治疗组（120例），患者术后每日均服用阿司匹林0.1 g及氯吡格雷75 mg，泮托拉唑治疗组在此基础上术前1d开始每日服用泮托拉唑40 mg。观察两组一年内心血管事件及消化道出血发生率。结果对照组与泮托拉唑治疗组总的心血管不良事件发生率分别为9.1%和10.0%，差异无统计学意义（P>0.05）。对照组和泮托拉唑治疗组总消化道出血事件发生率为10.8%和1.7%，泮托拉唑治疗组明显低于对照组，两组比较差异有统计学意义（P<0.05）。结论泮托拉唑预防冠脉支架术后消化道出血安全且有效。
목적탐토반탁랍서예방관맥지가술후소화도출혈적안전성급유효성。방법접수관맥지가술적환자240례수궤분위대조조(120례)급반탁랍서치료조（120례），환자술후매일균복용아사필림0.1 g급록필격뢰75 mg，반탁랍서치료조재차기출상술전1d개시매일복용반탁랍서40 mg。관찰량조일년내심혈관사건급소화도출혈발생솔。결과대조조여반탁랍서치료조총적심혈관불량사건발생솔분별위9.1%화10.0%，차이무통계학의의（P>0.05）。대조조화반탁랍서치료조총소화도출혈사건발생솔위10.8%화1.7%，반탁랍서치료조명현저우대조조，량조비교차이유통계학의의（P<0.05）。결론반탁랍서예방관맥지가술후소화도출혈안전차유효。
Objectives To investigate the safety and ef icacy of pantoprazole for the prevention of digestive tract bleeding in patients experienced coronary artery stent implantation. Methods Tow hundred and forty cases experienced coronary artery stent implantation were randomly divided into control group(120 cases)and pantoprazole treated group(120 cases), al patients after coronary artery stent implantation were administered clopidogrel 75 mg and aspirin 0.1 g per day, based on those pantoprazole treated group were administered pantoprazole 40mg per day. Occurrence of cardiovascular events and digestive tract bleeding were observed. Results The rate of cardiovascular events was 9.1%and 10.0% respectively in control group and pantoprazole treated group, the dif erence was not significant (P>0.05). The rate of digestive tract bleeding was obviously lower in pantoprazole treated group (1.7%) than that in control group (10.8%), the dif erence was significant (P<0.05). Conclusions pantoprazole was safe and ef ective to prevent digestive tract bleeding in patients experienced coronary artery stent implantation.