CAJ | 학술논문

目的：观察胸腔注入铜绿假单胞菌注射液治疗恶性胸腔积液的临床疗效。方法：将90例恶性胸腔积液患者随机分为治疗组31例，对照组A 29例，对照组B 30例。治疗组予以胸腔注入铜绿假单胞菌注射液治疗，对照组A和B分别予以胸腔注入顺铂和白介素-2治疗。比较3组临床疗效及不良反应。结果：治疗组总有效率80.6%，对照组A和对照组B的总有效率分别为51.7%和56.7%，治疗组有效率高于对照组，差异具有统计学意义（P<0.05），同时，治疗组严重不良反应发生率低。结论：胸腔注入铜绿假单胞菌注射液治疗恶性胸腔积液疗效明显，不良反应轻，值得临床推广应用。
목적：관찰흉강주입동록가단포균주사액치료악성흉강적액적림상료효。방법：장90례악성흉강적액환자수궤분위치료조31례，대조조A 29례，대조조B 30례。치료조여이흉강주입동록가단포균주사액치료，대조조A화B분별여이흉강주입순박화백개소-2치료。비교3조림상료효급불량반응。결과：치료조총유효솔80.6%，대조조A화대조조B적총유효솔분별위51.7%화56.7%，치료조유효솔고우대조조，차이구유통계학의의（P<0.05），동시，치료조엄중불량반응발생솔저。결론：흉강주입동록가단포균주사액치료악성흉강적액료효명현，불량반응경，치득림상추엄응용。
Objective:To observe the effect of thoracic infusion of pseudomonas aeruginosa injection in malignant pleural effusion. Methods:A total of 90 patients with malignant pleural effusion were randomly divided into treatment group (31 cases),control group A (29 cases) and control group B(30 cases). Treatment group was treated with pseudomonas aeruginosa through intrathoracic infusion. Control group A and B were respectively treated with cisplatin and interleukin-2 through intrathoracic infusion. The clinical efficacy and adverse reaction were compared among the three groups. Results:The total effective rate of treatment group was 80.6%,the total effective rates of the control group A and B were 51.7%and 56.7%respectively.Compared with that of contral groups, the total effective rate of treatment group was higher, and the differences were statistically significant (P<0.05). The incidence of serious side effects and toxicity was lower in treatment group than in control groups. Conclusion:The effect of thoracic infusion of pseudomonas aeruginosa injection for malignant pleural effusion is significant, and the adverse reaction is mild. Thus it is worth to be promoted clinically.