CAJ | 학술논문

目的：研究a-B晶体蛋白在三阴性乳腺癌（TNBC）中的表达，通过分析a-B晶体蛋白与乳腺癌临床、病理各指标之间的相关性，从而探讨其在TNBC的预后及靶向治疗中的作用。方法：采用免疫组织化学（IHC）S-P法检测30例TNBC，50例非TNBC的石蜡标本切片组织中的a-B晶体蛋白，比较TNBC与非TNBC组织中a-B晶体蛋白表达差异性，对a-B晶体蛋白表达与乳腺癌临床及病理指标间的关系进行相关性分析。结果：a-B晶体蛋白在TNBC中的阳性表达率为66.67%（20/30），明显高于在非TNBC中的表达率42.00%（21/50）（χ2=4.566，P<0.05）；a-B晶体蛋白在乳腺癌中的表达与年龄、肿瘤直径、肿瘤分期无明显差异（P>0.05）；与有无淋巴结转移、淋巴结转移个数、P53表达、ki-67表达有显著性差异（P<0.05），且呈正相关。a-B晶体蛋白在TNBC中的表达与年龄、肿瘤直径、有无淋巴结转移、淋巴结转移个数、肿瘤分期、P53表达、ki-67表达无相关性（P>0.05）。结论：a-B晶体蛋白的阳性表达在TNBC与非TNBC之间存在差异。a-B晶体蛋白在TNBC中高表达，且表达强度明显高于非TNBC。a-B晶体蛋白与乳腺癌预后不良相关，而a-B晶体蛋白在TNBC中的高表达可能为TNBC预后差的原因之一。
목적：연구a-B정체단백재삼음성유선암（TNBC）중적표체，통과분석a-B정체단백여유선암림상、병리각지표지간적상관성，종이탐토기재TNBC적예후급파향치료중적작용。방법：채용면역조직화학（IHC）S-P법검측30례TNBC，50례비TNBC적석사표본절편조직중적a-B정체단백，비교TNBC여비TNBC조직중a-B정체단백표체차이성，대a-B정체단백표체여유선암림상급병리지표간적관계진행상관성분석。결과：a-B정체단백재TNBC중적양성표체솔위66.67%（20/30），명현고우재비TNBC중적표체솔42.00%（21/50）（χ2=4.566，P<0.05）；a-B정체단백재유선암중적표체여년령、종류직경、종류분기무명현차이（P>0.05）；여유무림파결전이、림파결전이개수、P53표체、ki-67표체유현저성차이（P<0.05），차정정상관。a-B정체단백재TNBC중적표체여년령、종류직경、유무림파결전이、림파결전이개수、종류분기、P53표체、ki-67표체무상관성（P>0.05）。결론：a-B정체단백적양성표체재TNBC여비TNBC지간존재차이。a-B정체단백재TNBC중고표체，차표체강도명현고우비TNBC。a-B정체단백여유선암예후불량상관，이a-B정체단백재TNBC중적고표체가능위TNBC예후차적원인지일。
Objective: To investigate the expression of α-B crystalline in triple-negative breast cancer (TNBC) and discuss its role in the prognosis and targeted therapy of TNBC by analyzing the correlation amongα-B crystalline and the clinico-pathological indi-ces of breast cancer. Methods:Immunohistochemistry SP assay was used to determineα-B crystalline expression in paraffin-embedded specimens of 30 cases of TNBC and 50 cases of non-TNBC tissues. The differences in protein expressions among tissues were com-pared, and correlation analysis was performed to determine the relationship between protein expression and clinico-pathological indi-ces. Results:The positive expression rate ofα-B crystalline was 66.67%in TNBC (20/30) and 42.00%in non-TNBC (21/50), which in-dicates that the expression is significantly higher in TNBC than in the non-TNBC tissues (χ2=4.566, P<0.05). The expression ofα-B crystalline in breast cancer has no significant difference in terms of age, tumor diameter, and cancer stage (P>0.05), but exhibits a differ-ence in terms of lymph node metastasis and the number of metastasized lymph nodes [P53, Ki67 (P<0.05)], which presents a positive correlation (r=0.251). Theα-B crystalline expression in TNBC has no significant difference among indices such as age, tumor diameter, nodal metastasis, number of metastasis, P53, cancer stage, and Ki67 (P>0.05). Conclusion:Significant differences were found inα-B crystalline expression between TNBC and non-TNBC.α-B crystalline is highly expressed in TNBC tissues, and the expression is signif-icantly higher in TNBC tissues than that in non-TNBC tissues.α-B crystalline is associated with poor prognosis of breast cancer. Conse-quently, the overexpression ofα-B crystalline in TNBC may be a reason for unfavorable TNBC prognosis.