医药前沿
醫藥前沿
의약전연
YIAYAO QIANYAN
2014年
9期
114-115
,共2页
胎儿生长受限%胰岛素抵抗%二甲双胍%妊娠期糖尿病
胎兒生長受限%胰島素牴抗%二甲雙胍%妊娠期糖尿病
태인생장수한%이도소저항%이갑쌍고%임신기당뇨병
Insulin rejection%Fetal growth restriction%Metformin%Gestation diabetes mel itus
目的:探究孕前应用二甲双胍对胰岛素抵抗女性胎儿生长受限发生率的影响。方法选择2011年1月至2012年10月在我院妇产科门诊就诊的孕前咨询患者,对具有不良孕产史者进行胰岛素抵抗筛查,取经实验室证实胰岛素抵抗患者80例为研究对象。随机分为两组,即实验组和对照组1,并取无高危因素行孕前咨询正常孕妇40例作为对照组2。实验组孕前口服二甲双胍500mg tid,至胰岛素抵抗正常后再妊娠,对照(1和2)组自然妊娠。余处理三组相同。观察各组胎儿生长受限发病情况。结果实验组胎儿生长受限发生率较对照组1明显降低,具有统计学差异,与对照组2比较无统计学差异。结论孕前口服二甲双胍纠正胰岛素抵抗状况后,可改善患者孕期脐血流,降低胎儿生长受限发生率。
目的:探究孕前應用二甲雙胍對胰島素牴抗女性胎兒生長受限髮生率的影響。方法選擇2011年1月至2012年10月在我院婦產科門診就診的孕前咨詢患者,對具有不良孕產史者進行胰島素牴抗篩查,取經實驗室證實胰島素牴抗患者80例為研究對象。隨機分為兩組,即實驗組和對照組1,併取無高危因素行孕前咨詢正常孕婦40例作為對照組2。實驗組孕前口服二甲雙胍500mg tid,至胰島素牴抗正常後再妊娠,對照(1和2)組自然妊娠。餘處理三組相同。觀察各組胎兒生長受限髮病情況。結果實驗組胎兒生長受限髮生率較對照組1明顯降低,具有統計學差異,與對照組2比較無統計學差異。結論孕前口服二甲雙胍糾正胰島素牴抗狀況後,可改善患者孕期臍血流,降低胎兒生長受限髮生率。
목적:탐구잉전응용이갑쌍고대이도소저항녀성태인생장수한발생솔적영향。방법선택2011년1월지2012년10월재아원부산과문진취진적잉전자순환자,대구유불량잉산사자진행이도소저항사사,취경실험실증실이도소저항환자80례위연구대상。수궤분위량조,즉실험조화대조조1,병취무고위인소행잉전자순정상잉부40례작위대조조2。실험조잉전구복이갑쌍고500mg tid,지이도소저항정상후재임신,대조(1화2)조자연임신。여처리삼조상동。관찰각조태인생장수한발병정황。결과실험조태인생장수한발생솔교대조조1명현강저,구유통계학차이,여대조조2비교무통계학차이。결론잉전구복이갑쌍고규정이도소저항상황후,가개선환자잉기제혈류,강저태인생장수한발생솔。
Objective To evaluate The effect of Metformin to fetal growth restriction in patient with Insulin rejection before pregnancy. Methods From January of 2011 to October of 2012,80 patients with IR that were found out from the outpatient patients who have the pregnancy plan and some risk factors were invoved in this study.They were divided into two groups randomly ,40 treated with Metformin 500mg tid po. to the normal IR then suggested to pregnancy.40 as control group 1.40 normal with pregnancy play as control group 2. The contol s get pregnancy without any management.The rate of FGR were evaluated Results the FGR rate of Metformin management group is lower then controls. Conclusion Management with Metformin in patient with IR before pregnancy can improve the blood flow of umbil ocol cord and reduce the rate of FGR.