中国处方药
中國處方藥
중국처방약
CHINA PRESCRIPTION DRUG
2014年
4期
18-19
,共2页
双氯芬酸钠%肠溶片%粉末直接压片%溶出度
雙氯芬痠鈉%腸溶片%粉末直接壓片%溶齣度
쌍록분산납%장용편%분말직접압편%용출도
Diclofenac sodium%Enteric coated tablet%Direct powder compression%Dissolution rate
目的：制备更优质的双氯芬酸钠肠溶片。方法采用粉末直接压片及高效包衣机包衣法制备了双氯芬酸钠肠溶片，从片芯及包衣层两方面对处方进行筛选及优化。结果所制得的双氯芬酸钠肠溶片在人工胃液中耐酸力良好，在人工肠液中的溶出迅速且完全。结论研制了双氯芬酸钠肠溶片，解决了双氯芬酸钠对胃部刺激较大的问题，重现性好，工艺可行。
目的：製備更優質的雙氯芬痠鈉腸溶片。方法採用粉末直接壓片及高效包衣機包衣法製備瞭雙氯芬痠鈉腸溶片，從片芯及包衣層兩方麵對處方進行篩選及優化。結果所製得的雙氯芬痠鈉腸溶片在人工胃液中耐痠力良好，在人工腸液中的溶齣迅速且完全。結論研製瞭雙氯芬痠鈉腸溶片，解決瞭雙氯芬痠鈉對胃部刺激較大的問題，重現性好，工藝可行。
목적：제비경우질적쌍록분산납장용편。방법채용분말직접압편급고효포의궤포의법제비료쌍록분산납장용편，종편심급포의층량방면대처방진행사선급우화。결과소제득적쌍록분산납장용편재인공위액중내산력량호，재인공장액중적용출신속차완전。결론연제료쌍록분산납장용편，해결료쌍록분산납대위부자격교대적문제，중현성호，공예가행。
Objective Develop the diclofenac sodium enteric coated tablets.Methods Diclofenac sodium enteric coated tablets were prepared with direct powder compression method and coated using high efficiency coating machine and the formulation was screened and optimized from tablet core and the coating layer.Results The resistance to acid was good and the dissolution of the tablets was quick in artificial intestinal liquid. Conclusion Diclofenac sodium enteric-coated tablets was developed and the problem of stimulating to stomach by the diclofenac sodium was solved .The preparation process was feasible and replicable.
