CAJ | 학술논문

以5-甲(乙)基靛红1a-b为原料,在其氮上发生烃基化反应,以76．4-97．4%的产率合成了一系列N-烃基-5-甲(乙)基靛红2a-j,然后2a-j在水合肼作用下直接发生还原反应,以75．2-92．2%的产率得到了N-烃基-5-甲(乙)基吲哚酮3a-j。通过对两步反应的改进,达到了高产率、低成本和简便的目的。其中2f-j,3c和3e-j是未见文献报道的新化合物,其结构经红外光谱、质谱和核磁共振谱得以证实。
이5-갑(을)기전홍1a-b위원료,재기담상발생경기화반응,이76．4-97．4%적산솔합성료일계렬N-경기-5-갑(을)기전홍2a-j,연후2a-j재수합정작용하직접발생환원반응,이75．2-92．2%적산솔득도료N-경기-5-갑(을)기신타동3a-j。통과대량보반응적개진,체도료고산솔、저성본화간편적목적。기중2f-j,3c화3e-j시미견문헌보도적신화합물,기결구경홍외광보、질보화핵자공진보득이증실。
A series of N-alkyl-5-methyl/ethylindoline-2,3-diones 2a-j were synthesized in the yield of 76. 4-97. 4%through the al-kylation reaction of 5-methyl(ethyl)indoline-2,3-diones 1a-b. The resulting 2a-j were then underwent the reduction reaction with hydrazine hydrate directly to give N-alkyl-5-methyl( ethyl) indolin-2-ones 3a-j in the yield of 75. 2-92. 2%. The present synthetic route had the advantages such as high yield,low cost,and convenience. Among all the synthesized compounds,2f-j,3c and 3e-j were new compounds and their structures were confirmed by IR,MS,and1 H and 13 C NMR.