CAJ | 학술논문

多甲氧基菲-9-甲酸及酯是合成娃儿藤生物碱及其类似物的关键中间体。实验发现,以DTBP作为氧化剂,CaCl2存在下,能有效提高分子内氧化偶联合成多甲氧基菲-9-甲酸及酯产率,且反应条件温和,后处理方便,为合成许多重要化合物前体菲提供了一种新的思路。
다갑양기비-9-갑산급지시합성왜인등생물감급기유사물적관건중간체。실험발현,이DTBP작위양화제,CaCl2존재하,능유효제고분자내양화우연합성다갑양기비-9-갑산급지산솔,차반응조건온화,후처리방편,위합성허다중요화합물전체비제공료일충신적사로。
Polymethoxy-substituted phenanthrene-9-carboxylic acid or methylate is key intermediate for synthesis of tylophora alka-loids and analogues. Experiments showed that intramolecular oxidative coupling reaction of building polymethoxy-substituted phe-nanthrene-9-carboxylic acid or methylate by DTBP/CaCl2 gave good yields. The mild reaction condition,and easy post-treatment of this method provided us a new approach for the synthesis of phenanthrene ring.