CAJ | 학술논문

目的：探讨厄贝沙坦与苯磺酸氨氯地平联用对糖尿病肾病合并高血压的疗效。方法糖尿病肾病合并高血压92例，分为厄贝沙坦苯磺酸氨氯地平联合用药组和单用苯磺酸氨氯地平治疗的对照组。每组46例，连续治疗16个周，观察记录血压及肾功能变化。结果联合用药组的总有效率为93.4%，对照组总有效率为73.9%，两组比较差异有统计学意义（P＜0.01）。治疗后两组的收缩压（SBP）、舒张压（DBP）、血肌酐（SCr）、血尿素氮（BUN）、尿微量蛋白（mAlb）等均有明显降低，联合用药组降低更明显，两组比较差异有统计学意义（P＜0.05或P＜0.01）。两组均无明显不良反应。结论联合用药组疗效优于对照组，提示厄贝沙坦与苯磺酸氨氯地平联用治疗糖尿肾病合并高血压安全有效。
목적：탐토액패사탄여분광산안록지평련용대당뇨병신병합병고혈압적료효。방법당뇨병신병합병고혈압92례，분위액패사탄분광산안록지평연합용약조화단용분광산안록지평치료적대조조。매조46례，련속치료16개주，관찰기록혈압급신공능변화。결과연합용약조적총유효솔위93.4%，대조조총유효솔위73.9%，량조비교차이유통계학의의（P＜0.01）。치료후량조적수축압（SBP）、서장압（DBP）、혈기항（SCr）、혈뇨소담（BUN）、뇨미량단백（mAlb）등균유명현강저，연합용약조강저경명현，량조비교차이유통계학의의（P＜0.05혹P＜0.01）。량조균무명현불량반응。결론연합용약조료효우우대조조，제시액패사탄여분광산안록지평련용치료당뇨신병합병고혈압안전유효。
Objective To investigate the curative effect of Irbesartan Amlodipine Besylate on Diabetic Nephropathy Complicating Hypertension. Methods 92 diabetic nephropathy patients complicated with hypertension were randomly allocated into two groups. Both were treated for 16 consecutive weeks but with two different therapies. The experimental group was treated with Irbesartan and Amlodipine Besylate while the control group was treated with Amlodipine Besylate only. The results were recorded before and after the treatment to observe the changes of blood pressure and renal function. Results The total effective rate of the experimental group was 93.4% and that of the control group was 73.9%. Difference between the two groups has statistical significance(P<0.01). Both groups had an effect on the decrease of SBP, DBP, SCr, BUN and mAlb after the treatment but the experimental group led a more obvious decrease. Difference between the two groups has statistical significance(P<0.01 or P<0.05). No significant adverse reaction was observed. Conclusion The experimental group has a better curative effect than the control group. Thus, it is safe and effective to use Irbesartan Amlodipine Besylate to treat Diabetic Nephropathy Complicating Hypertension.