医学检验与临床
醫學檢驗與臨床
의학검험여림상
MEDICAL LATORATORY SCIENCE AND CLINICES
2013年
3期
27-29,50
,共4页
B细胞激活因子%多发性骨髓瘤%乳酸脱氢酶%β2-微球蛋白
B細胞激活因子%多髮性骨髓瘤%乳痠脫氫酶%β2-微毬蛋白
B세포격활인자%다발성골수류%유산탈경매%β2-미구단백
BAFF%Multiple meyloma%LDH%B2M
目的：探讨B细胞激活因子(BAFF)在多发性骨髓瘤（MM）中的表达水平。方法：用酶联免疫吸附测定法（ELISA）对31例MM患者和30名健康人血清BAFF含量进行检测；并比较MM患者血清BAFF含量与乳酸脱氢酶（LDH）、β2-微球蛋白（β2M）的相关性。结果：MM患者血清 BAFF含量明显高于健康对照组，并与LDH、β2M浓度呈正相关性。结论：MM患者的血清BAFF蛋白表达水平有异常改变，说明BAFF可能参与MM的发病；BAFF表达水平也许可作为预后的一个指标。
目的：探討B細胞激活因子(BAFF)在多髮性骨髓瘤（MM）中的錶達水平。方法：用酶聯免疫吸附測定法（ELISA）對31例MM患者和30名健康人血清BAFF含量進行檢測；併比較MM患者血清BAFF含量與乳痠脫氫酶（LDH）、β2-微毬蛋白（β2M）的相關性。結果：MM患者血清 BAFF含量明顯高于健康對照組，併與LDH、β2M濃度呈正相關性。結論：MM患者的血清BAFF蛋白錶達水平有異常改變，說明BAFF可能參與MM的髮病；BAFF錶達水平也許可作為預後的一箇指標。
목적：탐토B세포격활인자(BAFF)재다발성골수류（MM）중적표체수평。방법：용매련면역흡부측정법（ELISA）대31례MM환자화30명건강인혈청BAFF함량진행검측；병비교MM환자혈청BAFF함량여유산탈경매（LDH）、β2-미구단백（β2M）적상관성。결과：MM환자혈청 BAFF함량명현고우건강대조조，병여LDH、β2M농도정정상관성。결론：MM환자적혈청BAFF단백표체수평유이상개변，설명BAFF가능삼여MM적발병；BAFF표체수평야허가작위예후적일개지표。
Objective:To investgate the expression level of B lymphocyte stimulator (BAFF) in multiple meyloma (MM). Methods:Enzyme-Linked Immunosorbent Assay (ELISA) was used to test the serum level of BAFF between 31 MM patients and 30 healthy controls, and to find the relationship among the serum level of BAFF, lactic dehydrogenase (LDH) andβ2-microglobulin (β2M) in MM.Results:Serum level of BAFF in MM patients was significantly higher than that of healthy controls, and was positively correlated with the concentration of LDH andβ2M.Conclusions:There were abnormal changes in serum expression level of BAFF in MM patients, which means that BAFF may participate in the pathogenesis of MM, and the level of BAFF can also be a prognostic biomaker for MM.
