医学检验与临床
醫學檢驗與臨床
의학검험여림상
MEDICAL LATORATORY SCIENCE AND CLINICES
2013年
3期
16-17
,共2页
降钙素原%败血症%新生儿%改变
降鈣素原%敗血癥%新生兒%改變
강개소원%패혈증%신생인%개변
Procalcitonin%Sepsis%Neonate%Variations
目的:分析新生儿败血症患儿血中降钙素原(procalcitonin PCT)的动态改变。方法:采用免疫荧光定量法检测10例新生儿败血症患儿血中 PCT及10例缺血缺氧性脑病(HIE)的动态改变,同时以10例正常足月儿作为正常对照进行分析。结果:新生儿败血症患儿在急性期 PCT与正常对照组比较,数值明显升高,两者比较有统计学意义[(109.13±10.23)μg/L vs (6.87±1.12)μg/L],(P<0.01);经用抗生素治疗1周后降至正常范围(9.08±2.18)μg/L vs (8.15±2.65)μg/L,(P>0.05);而 HIE组患儿 PCT与正常对照组两者比较无明显的差异。结论:通过针对 PCT的检测,本研究者认为该方法操作方便,特定性强,可作为新生儿细菌感染检测的早期诊断的标志物,值得临床推广应用。
目的:分析新生兒敗血癥患兒血中降鈣素原(procalcitonin PCT)的動態改變。方法:採用免疫熒光定量法檢測10例新生兒敗血癥患兒血中 PCT及10例缺血缺氧性腦病(HIE)的動態改變,同時以10例正常足月兒作為正常對照進行分析。結果:新生兒敗血癥患兒在急性期 PCT與正常對照組比較,數值明顯升高,兩者比較有統計學意義[(109.13±10.23)μg/L vs (6.87±1.12)μg/L],(P<0.01);經用抗生素治療1週後降至正常範圍(9.08±2.18)μg/L vs (8.15±2.65)μg/L,(P>0.05);而 HIE組患兒 PCT與正常對照組兩者比較無明顯的差異。結論:通過針對 PCT的檢測,本研究者認為該方法操作方便,特定性彊,可作為新生兒細菌感染檢測的早期診斷的標誌物,值得臨床推廣應用。
목적:분석신생인패혈증환인혈중강개소원(procalcitonin PCT)적동태개변。방법:채용면역형광정량법검측10례신생인패혈증환인혈중 PCT급10례결혈결양성뇌병(HIE)적동태개변,동시이10례정상족월인작위정상대조진행분석。결과:신생인패혈증환인재급성기 PCT여정상대조조비교,수치명현승고,량자비교유통계학의의[(109.13±10.23)μg/L vs (6.87±1.12)μg/L],(P<0.01);경용항생소치료1주후강지정상범위(9.08±2.18)μg/L vs (8.15±2.65)μg/L,(P>0.05);이 HIE조환인 PCT여정상대조조량자비교무명현적차이。결론:통과침대 PCT적검측,본연구자인위해방법조작방편,특정성강,가작위신생인세균감염검측적조기진단적표지물,치득림상추엄응용。
Objective:To study the changes of serum procalcitonin(PCT) in neonates with sepsis. Methods:Serum PCT was determined using an immunorado metric assay in 10 newborn infants with neonatal sepsis,10 neonates with hypoxic-ischemic encephalopathy (HIE) and 10 healthy newborn controls.Results:Increased levels of serum PCT were found in neonates with sepsis compared with the control group [(110.12±11.12)μg/L vs(7.66±1.13)μg/L],(P<0.01). After 1 week of t reatment with appropriate antibiotics,PCT levels returned to normal(9.12±3.13)μg/L vs (7.65±2.67)μg/L,(P>0.05). There was no difference between HIE neonates and the control group.Conclusions:Elevated serum PCT levels are noted in neonatal sepsis. PCT might be of value in the diagnosis of neonatal sepsis.