医学检验与临床
醫學檢驗與臨床
의학검험여림상
MEDICAL LATORATORY SCIENCE AND CLINICES
2013年
3期
12-13,44
,共3页
唐氏综合征%产前筛查%二联筛查
唐氏綜閤徵%產前篩查%二聯篩查
당씨종합정%산전사사%이련사사
Down syndrome%Prenatal screening%Double screening
目的：比较不同时期二联筛查与传统孕中期二联筛查在唐氏综合征产前筛查中的效果。方法：采用罗氏电化学检测技术，对1289例同意接受产前筛查的孕妇及5例已确诊的唐氏综合征妊娠孕妇的冻存血清标本在孕周11~14周的孕妇测定PAPP-A、Freeβ-HCG，再于孕16~20周检测AFP、β-HCG浓度，分别计算不同时期二联筛查和传统孕中期二联筛查的风险值、检出率和假阳性率。结果：本研究中孕早期检出唐氏综合征高风险孕妇21例，孕中期检出高风险孕妇31例，其中包括一期高风险孕妇20例，共检出高风险孕妇32例，31例接受了羊膜腔穿刺检查，产前确诊1例，阳性率值为3.2%。32例筛查病例中，30~40岁者16例占（50.00%），可见高龄孕妇是唐氏综合征的危险人群。当截断值为1：270时,三联筛查与二联筛查对唐氏综合征的检出率均为65.2%；当截断值为1：380时，不同时期二联筛查的检出率明显高于孕中期传统二联法（p<0.05）。结论：在孕妇不同时期进行二联筛查是更有效的唐氏综合征筛查方法，有必要制定适合本地区人群的风险切割值,以提高产前筛查的筛查效率。
目的：比較不同時期二聯篩查與傳統孕中期二聯篩查在唐氏綜閤徵產前篩查中的效果。方法：採用囉氏電化學檢測技術，對1289例同意接受產前篩查的孕婦及5例已確診的唐氏綜閤徵妊娠孕婦的凍存血清標本在孕週11~14週的孕婦測定PAPP-A、Freeβ-HCG，再于孕16~20週檢測AFP、β-HCG濃度，分彆計算不同時期二聯篩查和傳統孕中期二聯篩查的風險值、檢齣率和假暘性率。結果：本研究中孕早期檢齣唐氏綜閤徵高風險孕婦21例，孕中期檢齣高風險孕婦31例，其中包括一期高風險孕婦20例，共檢齣高風險孕婦32例，31例接受瞭羊膜腔穿刺檢查，產前確診1例，暘性率值為3.2%。32例篩查病例中，30~40歲者16例佔（50.00%），可見高齡孕婦是唐氏綜閤徵的危險人群。噹截斷值為1：270時,三聯篩查與二聯篩查對唐氏綜閤徵的檢齣率均為65.2%；噹截斷值為1：380時，不同時期二聯篩查的檢齣率明顯高于孕中期傳統二聯法（p<0.05）。結論：在孕婦不同時期進行二聯篩查是更有效的唐氏綜閤徵篩查方法，有必要製定適閤本地區人群的風險切割值,以提高產前篩查的篩查效率。
목적：비교불동시기이련사사여전통잉중기이련사사재당씨종합정산전사사중적효과。방법：채용라씨전화학검측기술，대1289례동의접수산전사사적잉부급5례이학진적당씨종합정임신잉부적동존혈청표본재잉주11~14주적잉부측정PAPP-A、Freeβ-HCG，재우잉16~20주검측AFP、β-HCG농도，분별계산불동시기이련사사화전통잉중기이련사사적풍험치、검출솔화가양성솔。결과：본연구중잉조기검출당씨종합정고풍험잉부21례，잉중기검출고풍험잉부31례，기중포괄일기고풍험잉부20례，공검출고풍험잉부32례，31례접수료양막강천자검사，산전학진1례，양성솔치위3.2%。32례사사병례중，30~40세자16례점（50.00%），가견고령잉부시당씨종합정적위험인군。당절단치위1：270시,삼련사사여이련사사대당씨종합정적검출솔균위65.2%；당절단치위1：380시，불동시기이련사사적검출솔명현고우잉중기전통이련법（p<0.05）。결론：재잉부불동시기진행이련사사시경유효적당씨종합정사사방법，유필요제정괄합본지구인군적풍험절할치,이제고산전사사적사사효솔。
Objective:To comparison of different period of two CRC screening with the traditional two CRC screening in second trimester prenatal for Down's syndrome in effect. Methods:Using the Roche electrochemical detection technology,1289 cases accepted antenatal screening of pregnant women and5 patients who had been diagnosed with Down syndrome pregnancy of cryopreserved serum specimens in gestational weeks11 to14weeks of pregnancy determination of PAPP-A, Free beta-HCG, and then in 16~20 weeks pregnancy detection of AFP, HCG, concentration, were calculated for two screening and triple screening for risk value, the detection rate and false positive rate.Results:The study of early pregnancy detection of Down syndrome in 21 cases of high risk pregnant women, the second trimester detection of high risk pregnant women in 31 cases, including a period of high risk pregnant women in 20 cases, visible, there were32 cases of high risk pregnant women,31 cases underwent amnion cavity puncture examination, prenatal diagnosis in 1 cases, the positive rate is 3.2%. In 32 cases the screening case,30~40 years old accounted for 16 cases (50%), visible in women of advanced maternal age is down syndrome risk population.When the cut-off value of 1 to 270, with two triple screening for CRC screening for Down syndrome detection rates were65.2%;when the cut-off value of 1:380, different period two CRC screening detection rate was significantly higher than that of the traditional two CRC screening in( P<0.05) .Conclusions:In pregnant women during different periods of the traditional two CRC screening in second trimester prenatal is more effective for Down syndrome screening method, it is necessary to develop the region for the risk of cutting value, in order to improve prenatal screening efficiency.
