CAJ | 학술논문

目的：探讨EV71感染手足口病患儿血清儿茶酚胺水平的变化及意义。方法：采用高效液相色谱-电化学法测定70例EV71感染手足口病患儿（其中普通型50例，重症型20例）和10例健康儿童（对照组）的血清去甲肾上腺素（NE）、肾上腺素（E）和多巴胺（DA）水平，并分析其与血糖和白细胞计数等指标的相关性。结果：EV71感染手足口病患儿血清NE、E、DA水平均显著高于对照组（P<0.05），重症EV71感染组的血清NE水平显著高于普通EV71感染组（P<0.05），但两组间血清E和DA水平无明显差别（P>0.05）。重症EV71感染组的血糖和白细胞水平、头颅和上颈髓病变发生率均显著高于普通EV71感染组（P<0.05）。重症EV71感染患儿的血清NE水平与血糖、白细胞计数及头颅和上颈髓MRI病变之间均呈正相关，而血清E和DA水平与上述指标均无明显相关性（P>0.05）。结论：EV71感染手足口病患儿血清儿茶酚胺水平显著增加，其中去甲肾上腺素水平可作为重症病例的早期识别指标。
목적：탐토EV71감염수족구병환인혈청인다분알수평적변화급의의。방법：채용고효액상색보-전화학법측정70례EV71감염수족구병환인（기중보통형50례，중증형20례）화10례건강인동（대조조）적혈청거갑신상선소（NE）、신상선소（E）화다파알（DA）수평，병분석기여혈당화백세포계수등지표적상관성。결과：EV71감염수족구병환인혈청NE、E、DA수평균현저고우대조조（P<0.05），중증EV71감염조적혈청NE수평현저고우보통EV71감염조（P<0.05），단량조간혈청E화DA수평무명현차별（P>0.05）。중증EV71감염조적혈당화백세포수평、두로화상경수병변발생솔균현저고우보통EV71감염조（P<0.05）。중증EV71감염환인적혈청NE수평여혈당、백세포계수급두로화상경수MRI병변지간균정정상관，이혈청E화DA수평여상술지표균무명현상관성（P>0.05）。결론：EV71감염수족구병환인혈청인다분알수평현저증가，기중거갑신상선소수평가작위중증병례적조기식별지표。
Objective:To investigate the levels and clinical significance of serum catecholamine in children with hand-foot-mouth disease (HFMD) by EV71 infection. Methods:Serum norepinephrine, epinephrine and dopamine were measured by HPLC-ECD in 70 children with HFMD by EV71 infection and 20 healthy children. The relationship between serum catecholamine and blood glucose and white blood cells (WBC) were analyzed respectively.Results:Serum norepinephrine, epinephrine and dopamine levels of children with HFMD by EV71 infection were significantly higher than those in the control group (P<0.05). The norepinephrine levels were significant difference between subgroups of HFMD (P<0.05), but there was no significant difference of epinephrine and dopamine between the subgroups (P>0.05). Blood glucose, WBC count and pathological changes of skull and upper cervical cord of severe EV71 infection group were significantly higher than those in ordinary EV71 infection group (P<0.05). There were significantly positive correlations between serum norepinephrine, blood glucose, WBC count and pathological changes of skull and upper cervical cord in severe EV71 infection group (P<0.05), while no relationship between serum epinephrine and dopamine and these index (P>0.05).Conclusions:The levels serum catecholamine are significant increased in children with HFMD by EV71 infection, norepinephrine is a good indicators of the early diagnosis in severe EV71 infection children.