国际病毒学杂志
國際病毒學雜誌
국제병독학잡지
INTERNATIONAL JOURNAL OF VIROLOGY
2014年
3期
139-141
,共3页
麻疹%抗体%疫苗%免疫
痳疹%抗體%疫苗%免疫
마진%항체%역묘%면역
Measles%Antibody%Vaccines%Immunity
目的 调查北京市西城区健康人群麻疹抗体水平,为调整现有免疫策略、有效控制麻疹疫情,实现消除麻疹目标提供依据.方法 按容量比例概率抽样法(probability proportion to size,pps)抽样的方法,2012年在北京市西城区随机选择10个居委会,每个居委会随机抽取在京连续居住6个月以上的人员22名作为调查对象,共220名.采用面对面问卷调查收集调查对象的人口学特征、含麻疹成分疫苗免疫史,并采集静脉血5ml.使用ELISA方法检测研究对象麻疹IgG抗体水平.结果 调查对象麻疹抗体阳性率为85.91％,抗体水平中位数为976 IU ·l-1.不同年龄组人群中,麻疹抗体阳性率和抗体水平差异均具有统计学意义(x2=42.39,P＜0.01;H =38.84,P＜0.01),其中8月龄以下儿童抗体阳性率和抗体水平最低,分别为21.43％、120 IU·l-1;1～4岁、5～9岁儿童及40岁以上成人较高,阳性率均达95.45％,抗体水平中位数分别为3059 IU ·l-1、2099 IU·l-1、2308 IU·l-1;其余年龄组人群抗体阳性率在72.73％ ～ 95.45％之间,抗体水平在512 ～1679 IU·l-1之间.未接种过麻疹疫苗的人群麻疹抗体阳性率和抗体水平明显低于接种过疫苗和接种情况不详的人群(x2=28.73,P＜0.01;H =1.56,P＜0.01),差异有统计学意义.结论 北京市西城区常住人口中,1～9岁儿童麻疹抗体水平较高,发生大范围麻疹暴发和流行的风险较小,＜8月龄婴儿和15 ～ 40岁人群麻疹抗体水平有待进一步提高.
目的 調查北京市西城區健康人群痳疹抗體水平,為調整現有免疫策略、有效控製痳疹疫情,實現消除痳疹目標提供依據.方法 按容量比例概率抽樣法(probability proportion to size,pps)抽樣的方法,2012年在北京市西城區隨機選擇10箇居委會,每箇居委會隨機抽取在京連續居住6箇月以上的人員22名作為調查對象,共220名.採用麵對麵問捲調查收集調查對象的人口學特徵、含痳疹成分疫苗免疫史,併採集靜脈血5ml.使用ELISA方法檢測研究對象痳疹IgG抗體水平.結果 調查對象痳疹抗體暘性率為85.91％,抗體水平中位數為976 IU ·l-1.不同年齡組人群中,痳疹抗體暘性率和抗體水平差異均具有統計學意義(x2=42.39,P＜0.01;H =38.84,P＜0.01),其中8月齡以下兒童抗體暘性率和抗體水平最低,分彆為21.43％、120 IU·l-1;1～4歲、5～9歲兒童及40歲以上成人較高,暘性率均達95.45％,抗體水平中位數分彆為3059 IU ·l-1、2099 IU·l-1、2308 IU·l-1;其餘年齡組人群抗體暘性率在72.73％ ～ 95.45％之間,抗體水平在512 ～1679 IU·l-1之間.未接種過痳疹疫苗的人群痳疹抗體暘性率和抗體水平明顯低于接種過疫苗和接種情況不詳的人群(x2=28.73,P＜0.01;H =1.56,P＜0.01),差異有統計學意義.結論 北京市西城區常住人口中,1～9歲兒童痳疹抗體水平較高,髮生大範圍痳疹暴髮和流行的風險較小,＜8月齡嬰兒和15 ～ 40歲人群痳疹抗體水平有待進一步提高.
목적 조사북경시서성구건강인군마진항체수평,위조정현유면역책략、유효공제마진역정,실현소제마진목표제공의거.방법 안용량비례개솔추양법(probability proportion to size,pps)추양적방법,2012년재북경시서성구수궤선택10개거위회,매개거위회수궤추취재경련속거주6개월이상적인원22명작위조사대상,공220명.채용면대면문권조사수집조사대상적인구학특정、함마진성분역묘면역사,병채집정맥혈5ml.사용ELISA방법검측연구대상마진IgG항체수평.결과 조사대상마진항체양성솔위85.91％,항체수평중위수위976 IU ·l-1.불동년령조인군중,마진항체양성솔화항체수평차이균구유통계학의의(x2=42.39,P＜0.01;H =38.84,P＜0.01),기중8월령이하인동항체양성솔화항체수평최저,분별위21.43％、120 IU·l-1;1～4세、5～9세인동급40세이상성인교고,양성솔균체95.45％,항체수평중위수분별위3059 IU ·l-1、2099 IU·l-1、2308 IU·l-1;기여년령조인군항체양성솔재72.73％ ～ 95.45％지간,항체수평재512 ～1679 IU·l-1지간.미접충과마진역묘적인군마진항체양성솔화항체수평명현저우접충과역묘화접충정황불상적인군(x2=28.73,P＜0.01;H =1.56,P＜0.01),차이유통계학의의.결론 북경시서성구상주인구중,1～9세인동마진항체수평교고,발생대범위마진폭발화류행적풍험교소,＜8월령영인화15 ～ 40세인군마진항체수평유대진일보제고.
Objective To identify the level of measles antibody in healthy population,and provide scientific immunization strategy for the elimination of measles.Methods The subjects who had been living for over 6 months in Beijing were recruited for this study.Pps sample method was used to select 220 objects from 10 age groups.Demographic characteristics,vaccine immunization were investigated by questionnaire.The measles IgG antibody was measured by ELISA assay.Results Positive rate against measles antibody was 85.91％.Median of antibody was 976 IU · l-1.Positive rate and median of measles antibody were significantly different between population from different age groups(x2 =42.39,P ＜0.01 ;H =38.84,P ＜0.01).Antibody positive rate and median were lowest in the ＜ 8 month age group,which were separately 21.43％,120 IU · l-1 ;and highest in the 1-4,5-9 and ＞40 year age group,their positive rate all reach 95.45％ and median were separately 3059 IU · l-1,2099 IU · l-1,2308 IU · l-1.The range of antibody positive rate and median in other year group were 72.73％ ～95.45％ and 512 ～ 1679 IU · l-1,respectively.Antibody positive rate and median in population without vaccination history were lower than those population with vaccination history and people whose history unknown.The difference showed statistical significance (x2 =28.73,P ＜ 0.01 ;H =1.56,P ＜ 0.01).Conclusions Among the persistent population in Beijing,measles antibody level among the children ag(1-9 years old) was high enough to prevent outbreak and epidemic of measles.However,we should try our best to strengthen the measles antibody level among the babies younger than 8 month and population aging between 15 and 40 years old.
