CAJ | 학술논문

目的：探讨创伤性脑损伤后骨折愈合加快的病理、生理机制。方法：在Pubmed、中国知网等数据库查阅有关颅脑损伤合并骨折后骨折愈合加快研究的文献，进行汇总分析。结果：创伤性脑损伤后，患者血液、局部组织中骨折愈合相关的细胞因子、神经肽、瘦素等表达升高，促进成骨作用，加速骨折愈合；而生长激素等体液激素的高表达、即刻基因的高表达、骨折端微动及组织异位骨化也是愈合加速的关键因素。结论：创伤性脑损伤后，骨折在体液、机械、细胞因子及其他相关因素等多方面因素影响下加速愈合，但其具体作用机制尚未明了，有待进一步研究。
목적：탐토창상성뇌손상후골절유합가쾌적병리、생리궤제。방법：재Pubmed、중국지망등수거고사열유관로뇌손상합병골절후골절유합가쾌연구적문헌，진행회총분석。결과：창상성뇌손상후，환자혈액、국부조직중골절유합상관적세포인자、신경태、수소등표체승고，촉진성골작용，가속골절유합；이생장격소등체액격소적고표체、즉각기인적고표체、골절단미동급조직이위골화야시유합가속적관건인소。결론：창상성뇌손상후，골절재체액、궤계、세포인자급기타상관인소등다방면인소영향하가속유합，단기구체작용궤제상미명료，유대진일보연구。
Objective:To discuss the reason , research status and development of accelerating fracture healing after traumatic craniocerebral injury .Methods:To look into such literatures concerning accelerating fracture healing after craniocerebral injury complicated with fracture in database PubMed , CNKI and so on, to summarize and analyze the results .Results:Expression of cytokines , neuropeptides , and leptin refered during blood and local tissue elevated after traumatic craniocerebral injury , and they promoted bone formation , acceler-ated fracture healing as well .Elevated expression of growth hormone and other body fluids hormone ,immediate high expression of the gene , the fracture micro and organizations heterotopic ossification was also a key factor in healing accelerated .Conclusions:Fracture healing after traumatic craniocerebral injury was accelerated by mul-tifaceted impact of body fluid , mechanics, cytokines, and other relevant factors , but the specific mechanism of action is not clear yet and it still needs a further study .