医学检验与临床
醫學檢驗與臨床
의학검험여림상
MEDICAL LATORATORY SCIENCE AND CLINICES
2013年
4期
53-54,16
,共3页
甲减%Graves病%131I%优甲乐
甲減%Graves病%131I%優甲樂
갑감%Graves병%131I%우갑악
hypothyroidism%Graves disease%131I%Euthyrox
目的：不同剂量的优甲乐(L-T4)对131I治疗甲亢后早发甲减的影响。方法：218例Graves病患者，按照随机分组分为3组，A组69例，单纯给予131I治疗作为对照组；B组78例，131I治疗后21天起用L-T425ug/d连续治疗20天；C组71例，131I治疗后21天起用L-T4100ug/d连续治疗20天；通过测定甲功观察131I治疗后早发甲减发生率及首次甲亢治愈率。结果：131I治疗后3月、6月、12月甲减的发生率及首次甲亢的治愈率A组分别为8.72%、12.33%、20.28%，81.16%；B组分别为4.29%、5.49%、7.69%、76.92%；C组分别为4.37%、5.02%、7.04%、61.97%。结论：小剂量的优甲乐能降低131I治疗后早发甲减的发生率，同时甲亢的治愈率又不下降。
目的：不同劑量的優甲樂(L-T4)對131I治療甲亢後早髮甲減的影響。方法：218例Graves病患者，按照隨機分組分為3組，A組69例，單純給予131I治療作為對照組；B組78例，131I治療後21天起用L-T425ug/d連續治療20天；C組71例，131I治療後21天起用L-T4100ug/d連續治療20天；通過測定甲功觀察131I治療後早髮甲減髮生率及首次甲亢治愈率。結果：131I治療後3月、6月、12月甲減的髮生率及首次甲亢的治愈率A組分彆為8.72%、12.33%、20.28%，81.16%；B組分彆為4.29%、5.49%、7.69%、76.92%；C組分彆為4.37%、5.02%、7.04%、61.97%。結論：小劑量的優甲樂能降低131I治療後早髮甲減的髮生率，同時甲亢的治愈率又不下降。
목적：불동제량적우갑악(L-T4)대131I치료갑항후조발갑감적영향。방법：218례Graves병환자，안조수궤분조분위3조，A조69례，단순급여131I치료작위대조조；B조78례，131I치료후21천기용L-T425ug/d련속치료20천；C조71례，131I치료후21천기용L-T4100ug/d련속치료20천；통과측정갑공관찰131I치료후조발갑감발생솔급수차갑항치유솔。결과：131I치료후3월、6월、12월갑감적발생솔급수차갑항적치유솔A조분별위8.72%、12.33%、20.28%，81.16%；B조분별위4.29%、5.49%、7.69%、76.92%；C조분별위4.37%、5.02%、7.04%、61.97%。결론：소제량적우갑악능강저131I치료후조발갑감적발생솔，동시갑항적치유솔우불하강。
Objective:to study the impact of interference on the 131I treatment used to treat hyperthyrosis through different does of Euthyrox (L-T4 )on the early hypothyroidism. Methods:to divide the 218 samples of Graves disease patients into 3 random groups. Group A contained 69 samples, compared with the control group only treated by 131I;Group B had 78 samples, using 131I I for the first 21 day and L-T4 25ug/d for the next successive 20 days;Group C had 71 samples, using L-T4 100ug/d for a successive 20 days after the treatment in 131I for 21 days;The early hypothyroidism rate and the cure rate of hyperthyrosis were observed by measurement of thyroid function. Results:the early hypothyroidism rate and the cure rate of hyperthyrosis of group A after 3, 6, 12 months treated by 131I were 8.72%, 12.33%, 20.28%, and 81.16%respectively. Group B was 4.29%, 5.49%, 7.69%, and 76.92%. Group C was 4.37%, 5.02%, 7.04%, and 61.97%. Conclusions:smal does of Euthyrox could reduce the early hypothyroidism rate after using 131I I, and would not reduce the cure rate of hyperthyrosis.
