医学检验与临床
醫學檢驗與臨床
의학검험여림상
MEDICAL LATORATORY SCIENCE AND CLINICES
2013年
4期
48-50
,共3页
重症监护病房%监测%耐药性
重癥鑑護病房%鑑測%耐藥性
중증감호병방%감측%내약성
ICU%Monitor%Drug resistance
目的：了解我院重症监护病房（ICU）病原菌的分布特点及耐药性，为临床抗感染治疗提供理论依据。方法：采用纸片法、MIC法进行抗菌药物敏感性试验，使用WHONET5.6软件对我院2009年1月1日至2013年4月15日ICU来源的患者首次分离菌株进行分析。结果：共检出374株病原菌，其中革兰阴性杆菌67.4%，革兰氏阳性杆菌32.6%，前3位分别为鲍曼不动杆菌104株（27.8%）、铜绿假单胞菌48株（12.8%）、金黄色葡萄球菌40株（10.7%）；耐甲氧西林西林金黄色葡萄球菌和凝固酶阴性葡萄球菌的检出率分别为72.5%和52.7%，未发现耐万古霉素和耐利奈唑胺葡萄球菌；未见对万古霉素耐药的粪肠球菌和屎肠球菌；产ESBLs大肠埃希菌和肺炎克雷伯菌的比率分别为61.5％和72.2％；鲍曼不动杆菌对碳青霉烯类抗菌药物的耐药率达57.6％，检出泛耐药鲍曼不动杆菌30株。结论：ICU分离菌株对常用抗菌药物的耐药率较高，应采取积极措施加以控制。
目的：瞭解我院重癥鑑護病房（ICU）病原菌的分佈特點及耐藥性，為臨床抗感染治療提供理論依據。方法：採用紙片法、MIC法進行抗菌藥物敏感性試驗，使用WHONET5.6軟件對我院2009年1月1日至2013年4月15日ICU來源的患者首次分離菌株進行分析。結果：共檢齣374株病原菌，其中革蘭陰性桿菌67.4%，革蘭氏暘性桿菌32.6%，前3位分彆為鮑曼不動桿菌104株（27.8%）、銅綠假單胞菌48株（12.8%）、金黃色葡萄毬菌40株（10.7%）；耐甲氧西林西林金黃色葡萄毬菌和凝固酶陰性葡萄毬菌的檢齣率分彆為72.5%和52.7%，未髮現耐萬古黴素和耐利奈唑胺葡萄毬菌；未見對萬古黴素耐藥的糞腸毬菌和屎腸毬菌；產ESBLs大腸埃希菌和肺炎剋雷伯菌的比率分彆為61.5％和72.2％；鮑曼不動桿菌對碳青黴烯類抗菌藥物的耐藥率達57.6％，檢齣汎耐藥鮑曼不動桿菌30株。結論：ICU分離菌株對常用抗菌藥物的耐藥率較高，應採取積極措施加以控製。
목적：료해아원중증감호병방（ICU）병원균적분포특점급내약성，위림상항감염치료제공이론의거。방법：채용지편법、MIC법진행항균약물민감성시험，사용WHONET5.6연건대아원2009년1월1일지2013년4월15일ICU래원적환자수차분리균주진행분석。결과：공검출374주병원균，기중혁란음성간균67.4%，혁란씨양성간균32.6%，전3위분별위포만불동간균104주（27.8%）、동록가단포균48주（12.8%）、금황색포도구균40주（10.7%）；내갑양서림서림금황색포도구균화응고매음성포도구균적검출솔분별위72.5%화52.7%，미발현내만고매소화내리내서알포도구균；미견대만고매소내약적분장구균화시장구균；산ESBLs대장애희균화폐염극뢰백균적비솔분별위61.5％화72.2％；포만불동간균대탄청매희류항균약물적내약솔체57.6％，검출범내약포만불동간균30주。결론：ICU분리균주대상용항균약물적내약솔교고，응채취적겁조시가이공제。
Objective:To investigate the bacterial distribution and drug resistance among clinical isolates from ICU in our hospital. Methods:Disk diffusion test and MIC test were used to detect the antimicrobial sensitivity of clinical isolates from ICU in our hospital from Jan 1, 2009 to Apr 15, 2013, and the data were analyzed by WHONET 5.6 according to CLSI 2012 criteria.Results:A total of 374 clinical isolates were isolated during the survey period from ICU, of which gram negative rods and gram positive cocci accounted for 67.4%and 32.6%respectively, Acinetobacter baumannii (104 strains, 27.8%), Pseudomonas aeruginosa (48 strains, 12.8%) and Staphylococus aureus (40 strains, 10.7%) were the three most common isolated species. The methicil in-resistant Staphylococcus aureus and coagulase-negative Staphylococci were 72.5%and 52.7%respectively. No strains of vancomycin-resistant or linezolid-resistant Staphylococci were detected. The rates of ESBLs-producing Escherichia coli and Klebsiel a pneumonia were 61.5%and 72.2%respectively. The carbapenem-resistant rate of Acinetobacter baumannii was over 57.6%, a total of 30 strains of pan-resistant Acinetobacter baumannii were detected out.Conclusions:Bacterial resistance in ICU is serious, effective measures should be taken to control it.
